Thygeson's Superficial Punctate Keratitis

Superficial Punctate Keratitis of Thygeson
  • Uncommon, non-contagious, primary corneal inflammation of unknown etiology.

Clinical Features

  • Symptoms:
    • Patients usually present with bilateral keratitis
    • Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years.
  • Signs:
    • Superficial coarse, punctate, discrete gray epithelial opacities which protrude into the tear film
    • More often located centrally
    • Usually remain for several weeks to several months and eventually fade
    • The conjunctiva is not involved.


  • Mild symptoms may be treated with simple lubricants.
  • Low dose corticosteroids and topical cyclosporine are usually effective to reduce the duration of the recurrence.