Pulmonary, Allergy, and Critical Care

Cystic Fibrosis Clinical Trials

PROMISE

  • ClinicalTrials.gov: NCT04038047
  • A prospective study to evaluate biological and clinical effects of significantly corrected CFTR function (the PROMISE Study).

NTM PREDICT Trial

  • ClinicalTrials.gov: NCT02073409
  • Prospective Evaluation of NTM Disease In Cystic Fibrosis. The study is observational in nature, and is designed to advance understanding of nontuberculous mycobacteria (NTM) infection and facilitate the decision making process regarding treatment. (Cystic Fibrosis Foundation).

NTM PATIENCE Trial

  • ClinicalTrials.gov: NCT02419989
  • Prospective Algorithm for Treatment of NTM in Cystic Fibrosis. This trial tests the feasibility of a standardized treatment algorithm for confirmed infection with either M. avium complex or the M. abscessus complex. (Cystic Fibrosis Foundation).

MAYFLOWERS Trial

  • ClinicalTrials.gov:​​​​​​​​​​​​​​ NCT04828382
  • In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators.

Phase 1 / 2 Trial of SP-101 for the Treatment of Cystic Fibrosis (SAAve)

  • ClinicalTrials.gov:​​​​​​​​​​​​​​ NCT06526923
  • This is a nebulized genetic therapy for people with cystic fibrosis who are not on CFTR modulators

Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

  • ClinicalTrials.gov:​​​​​​​​​​​​​​ NCT06016088
  • This is a nebulized tobramycin with CaEDTA, for people with cystic fibrosis and Pseudomonas aeruginosa infection

Phase 1 / 2 Stury of VX-522 in Participants with Cystic Fibrosis

  • ClinicalTrials.gov:​​​​​​​​​​​​​​ NCT05668741
  • This is a nebulized genetic therapy for people with cystic fibrosis who are not on CFTR modulators