Asthma Clinical Trials

MATCH: Medication Adherence With Telehealthcare Medication Therapy Management (MATCH)

  • This is a study to determine if electronic asthma monitoring plus telehealth intervention with a pharmacist improves asthma control beyond electronic monitoring alone.
  • Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an at-risk population of Adolescents and Young Adults (AYA) with uncontrolled asthma who have poor adherence with prescribed Inhaled corticosteroid (ICS) therapy.
  • ClinicalTrials.gov: NCT03978936

PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study

  • This study evaluates the effectiveness of various therapies for patients with uncontrolled asthma, with therapies based on specific characteristics of the individual¬†patient's asthma.
  • PrecISE is a clinical study sponsored by the U.S. National Heart, Lung, and Blood Institute (NHLBI) to investigate several treatments for severe asthma. PrecISE will enroll 600 adults and teenagers (ages 12 years and older) with severe asthma who have symptoms that are not well-controlled on high dose of inhaled corticosteroids including those who have frequent asthma attacks. Each person who agrees to enroll in the PrecISE study will receive several treatments for research purposes based on their type of severe asthma.
  • The goal of PrecISE is to understand how to treat different types of severe asthma, by using precision medicine. Precision medicine is an approach that targets treatments to defined subgroups of patients who share similar characteristics, for example, patients with a certain genetic variation or patients with high number of blood eosinophils.
  • ClinicalTrials.gov: NCT04129931

GINGER: Ginger's Therapeutic Potential in Asthma (GINGER)

  • This study evaluates the effectiveness of oral ginger compared with placebo in patients with uncontrolled asthma.
  • Presently an estimated 25.9 million Americans suffer from asthma and over half have at least one asthma attack per year. Recent studies found that 60% of moderate asthmatics and 70% of severe asthmatics report using complementary and alternative medicine (CAM) to self-treat their asthma symptoms. The exact mechanism of action of these agents is unclear but may involve attenuation of allergic response, anti-inflammatory and antioxidant effects, and/or direct effects on airway smooth muscle which are responsible for airway narrowing in asthma.
  • Clinical trials with chronic oral ginger therapy in humans have demonstrated safe consumption of 2 grams per day for 28 days with demonstrated anti-inflammatory effects in colon cancer and inflammatory bowel diseases. Thus, the investigators hypothesize that oral ginger at a dose of 2 grams per day will reduce airway inflammation and will reduce serum levels of asthma related inflammatory markers.
  • ClinicalTrials.gov: NCT03705832