Posterior Polymorphous Dystrophy

Posterior Polymorphous Dystrophy
  • A slowly progressive, uncommon, dominantly inherited condition.

Clinical Features

  • Usually bilateral but often asymmetric.
  • Variable clinical features include isolated or coalescent posterior corneal vesicular (the most distinctive characteristic), multi-layered Descemet's membrane thickening and band-like configuration with sharp scalloped margin.
  • The peripheral abnormal multi-layered endothelial cells may cause localized iridocorneal adhesion.
  • Symptom: most cases are asymptomatic and do not require treatment.
  • If the condition progresses to corneal decompensation, definitive treatment with penetrating keratoplasty is usually required.