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The research of Ana Kim, MD, and her lab involves exploring the effect of noise-induced hearing loss and prolonged hearing loss on the central auditory pathway using a mouse model.
Neurofilaments (NFs) are heteropolymers made of three different subunits: light, medium, and heavy (NFL, NFM, and NFH, respectively). These subunits assemble into 10 nm filaments that compose the main part of the axonal cytoskeleton. Mutations in NFL are thought to disrupt NF assembly and axonal transport, which results in the accumulations of NFs leading to axonal degeneration. Recently, a knock-in mouse model bearing the N98S mutation has been generated. The NeflN98S/+ mouse model is used to test potential treatments for hearing loss caused by the disruption of NF assembly.
Hunki Paek, PhD
Associate Research Scientist