Selected Publications

  • Wu WH, Tsai YT, Huang IW, Cheng CH, Hsu CW, Cui X, Ryu J, Quinn PMJ, Caruso SM, Lin CS, and Tsang SH. CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa. Molecular Therapy. 2022.
  • Tsai TY, Li Y, Ryu J, Su PY, Cheng CH, Wu WH, Li YS, Quinn PMJ, Leong KW, and Tsang SH. Impaired cholesterol efflux in retinal pigment epithelium of individuals with juvenile macular degeneration. The American Journal of Human Genetics. 2021.
  • Oh JK, Tsang SH. Stargardt Juvenile Macular Degeneration. New England Journal of Medicine. 2020.
  • Zuccaro MV, Xu J, Mitchell C, Marin D, Zimmerman R, Rana B, Weinstein E, King RT, Palmerola KL, Smith ME, Tsang SH, Goland R, Jasin M, Lobo R, Treff N, Egli D. Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos. Cell. 2020.
  • Sagi I, Pinho JCD, Zuccaro MV, Atzmon C, Golan-Lev T, Yanuka O, Prosser R, Sadowy A, Perez G, Cabral T, Glaser B, Tsang SH, Goland R, Sauer MV, Lobo R, Benvensity and N, Egli D. Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells. Cell Stem Cell. 2019.
  • Koch SF, Duong JK, Hsu CW, Tsai YT, Lin CS, Wahl-Schott CA, and Tsang SH. Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa. PNAS. 2017.
  • Zhang L, Du J, Justus S, Hsu CW, Bonet-Ponce L, Wu WH, Tsai YT, Wu WP, Jia Y, Duong JK, Mahajan VB, Lin CS, Wang S, Hurley JB, and Tsang SH. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. Journal of Clinical Investigation. 2016
  • Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, and Tsang SH. Gene Therapy in Patient-specific Stem Cell Lines and a Preclinical Model of Retinitis Pigmentosa With Membrane Frizzled-related Protein Defects. Molecular Therapy. 2014.
  • Tsang SH, Burns ME, Calvert PD, Gouras P, Baylor DA, Goff SP, and Arshavsky VY. Role for the Target Enzyme in Deactivation of Photoreceptor G Protein in Vivo. Science. 1998.
  • Tsang SH, Gouras P, Yamashita CK, Kjeldbye H, Fisher J, Farber DB, and Goff SP. Retinal Degeneration in Mice Lacking the γ Subunit of the Rod cGMP Phosphodiesterase. Science. 1998.