Institute for Cancer Genetics

Recent Publications

  1. Stress-driven strategic games in cancer
    Ozcan SC
    Biosystems. 2026.
     
  2. Deciphering protein mutation-phenotype linkages from CRISPR-based tiling mutagenesis screens
    He W, Huang JW, Wang Y, Hayward SB, Leuzzi G, Fu R, Wang S, Vaitsiankova A, Chen Y, Bedford MT, Guerois R, Ciccia A, Xu H
    Cell Syst. 2026.
     
  3. The Evolution of Radiotherapy in Children's Oncology Group Trials, from 1998-2025
    Gallitto M, Zhang H, Iandoli M, Fitzgerald TJ, Kalapurakal JA, Krasin MJ, Haas-Kogan DA, Paulino AC, Laack NNI, Wolden SL, Hoppe BS, Hill-Kayser CE, Mahajan A, Yock TI
    Int J Radiat Oncol Biol Phys. 2026.
     
  4. eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression
    Powers J, Wei L, Cheung JCT, Ahmadi P, Kobayashi H, Curiel-Garcia A, Kang S, Valenzuela E, Jovanovic M, Chavez A, Chio IIC
    Cancer Res. 2026.
     
  5. SMARCAL1 is a candidate therapeutic target for ALT-positive tumors
    Taglialatela A, Lee J, Azeroglu B, Chen X, Dello Stritto MR, Gouge A, Lama-Diaz T, Vaitsiankova A, Leuzzi G, Dela Cruz F, Khan ZF, Kung AL, Cejka P, Lazzerini Denchi E, Min J, Ciccia A
    Genes Dev. 2026.
     
  6. Correction: SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle
    Lu YF, Xu XP, Lu XP, Zhu Q, Liu G, Bao YT, Wen H, Li YL, Gu W, Zhu WG
    Oncogene. 2026.
     
  7. Ku70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of the Ku ring along DNA
    Zhu Y, Jonchhe S, Zhang H, Lee BJ, Lin X, Fujii S, Li A, Vu DD, Wang KJ, Rothenberg E, Modesti M, Zha S
    Nucleic Acids Res. 2026.
     
  8. Differential role of CREBBP missense and truncating mutations in germinal center development and lymphomagenesis
    Yu C, Holloman M, Kim A, Chang Y, Meyer SN, Holmes AB, Cai B, Mo T, Basso K, Dreval K, Morin RD, Bhagat G, Mullighan CG, Dalla-Favera R, Pasqualucci L
    Blood. 2026.
     
  9. Endogenous Sources of Abasic Sites and Implications for DNA Replication: Mechanisms of Fork Stalling and Recovery
    Taglialatela A, Ciccia A
    Annu Rev Biochem. 2026.
     
  10. A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression
    Xia Z, Yang X, Samovich SN, Tyurina YY, Tyurin VA, Kon N, Zhang J, Jiang X, Stockwell BR, Jin J, Bayir H, Kagan VE, Gu W
    Cell. 2026.
     
  11. The Moving Target: Cis-Mutation-Driven Resistance to p53-Y220C Reactivator
    Liu Y, Gu W
    Cancer Discov. 2026.
     
  12. Nonhomologous end joining-the importance of end tethering and beyond
    Zha S, Yi G
    Genes Dev. 2026.
     
  13. Consensus recommendations from the 2024 International Follicular Lymphoma Scientific Workshop
    Merryman R, Rutherford SC, Ansell S, Armand P, Leonard JP, Nastoupil L, Smith SM, Timmerman J, Zelenetz AD, Gutierrez M, Béguelin W, Casulo C, Cerhan J, Green M, Kahl B, Kridel R, Link B, Maurer MJ, Nadel B, Radtke AJ, Luttwak E, Salles G, Sehn L, Pasqualucci L, LaCasce AS
    Blood Adv. 2026.
     
  14. Editorial Expression of Concern: Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
    Chen D, Shan J, Zhu WG, Qin J, Gu W
    Nature. 2026.
     
  15. Visualization and quantification of rDNA instabilities in mammalian cells and mouse models
    Zhu X, Jiang W, Wu W, Lee BJ, Menolfi D, Tubbs A, Cupo OM, Malkovskiy E, Nester M, Wang XS, Sims PA, Lin CV, Symington L, Nussenzweig A, McStay B, Zha S
    Nucleic Acids Res. 2026.
     
  16. Activation of T Cell-Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy
    Yan X, Xu W, Yao H, Wu Z, Ning J, Zhao S, Liu Y, Zhang M, Xu D, Shen Z, Gu W, Wang D
    Cancer Discov. 2026.
     
  17. Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing
    Yu T, Yoon J, Zhu Y, Li A, Lee BJ, Moakley DF, Duan J, Deng Q, Hou F, Yan M, Gennarino VA, Zhang K, Chen L, Zha S, Zhang C
    bioRxiv. 2025.
     
  18. Therapeutic outlooks for Gal-1 and genotoxic agents
    Sohn EJ, Min J
    FEBS J. 2025.
     
  19. Deep Generative AI for Multi-Target Therapeutic Design: Toward Self-Improving Drug Discovery Framework
    Kang SI, Shin JH, Wu BM, Choi HS
    Int J Mol Sci. 2025.
     
  20. The PURB-HOTAIR complex regulates p53-dependent promoter-specific transcriptional activation
    Xia Z, Kon N, Su Z, Yi J, Hua X, Zhou H, Zhang Z, Gu W
    Nat Struct Mol Biol. 2025.
     
  21. Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers
    Lee J, Sohn EJ, Lee J, Cheng AY, Taglialatela A, Ciccia A, Min J
    Nucleic Acids Res. 2025.
     
  22. Weight loss in patients on osimertinib for metastatic EGFR-mutant non-small cell lung cancer
    Chen LN, Ma X, Herzberg B, Henick BS, Biswas AK, Acharyya S, Shu CA
    Oncologist. 2025.
     
  23. p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases
    Liu Y, Stockwell BR, Jiang X, Gu W
    Nat Rev Mol Cell Biol. 2025.
     
  24. Ku limits RNA-induced innate immunity to allow Alu expansion in primates
    Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild-Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S
    Nature. 2025.
     
  25. Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
    Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Chen C', Paiva M, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT
    Nat Biotechnol. 2025.
     
  26. Dual Role of NRF2 in Pancreatic Precursor Lesions
    Ichimiya S, Ahn SS, Dixon MS, O'Sullivan JP, DeVine LC, Chen A, Yamamoto T, Oda Y, Nakamura M, Chio IIC
    Cancer Res Commun. 2025.
     
  27. Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
    Karri S, Dickinson Q, Li Z, Yu C, Zhang Z
    J Vis Exp. 2025.
     
  28. The replication stress response: Mechanisms and functions
    Ciccia A, Vindigni A
    DNA Repair (Amst). 2025.
     
  29. Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers
    Lee J, Sohn EJ, Lee J, Taglialatela A, Ciccia A, Min J
    bioRxiv. 2025.
     
  30. A new, immunocompetent brain-metastatic mouse model of HER2-positive breast cancer
    Chen L, Chow A, Ma W, Coker C, Gu Y, Canoll P, Kandpal M, Hibshoosh H, Biswas AK, Acharyya S
    Clin Exp Metastasis. 2025.
     

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