Institute for Cancer Genetics

Recent Publications

  1. CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma
    Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, Gallitto M, Barron T, Taylor KR, Woo PJ, Hua X, Zhou H, Wei HJ, McQuillan N, Kang KD, Friedman GK, Canoll PD, Chang K, Wu CC, Hashizume R, Vakoc CR, Monje M, McKhann GM, Gogos JA, Zhang Z
    Cancer Discov. 2024.
     
  2. PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression
    Yang X, Gu W
    J Mol Cell Biol. 2024.
     
  3. Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)
    Hu X, Kabir M, Lin Y, Xiong Y, Parsons RE, Gu W, Jin J
    J Med Chem. 2024.
     
  4. MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis
    Yu C, Shen Q, Holmes AB, Mo T, Tosato A, Soni RK, Corinaldesi C, Koul S, Pasqualucci L, Hussein S, Forouhar F, Dalla-Favera R, Basso K
    Nat Commun. 2024.
     
  5. FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer
    Tai Y, Chow A, Han S, Coker C, Ma W, Gu Y, Estrada Navarro V, Kandpal M, Hibshoosh H, Kalinsky K, Manova-Todorova K, Safonov A, Walsh EM, Robson M, Norton L, Baer R, Merghoub T, Biswas AK, Acharyya S
    EMBO Mol Med. 2024.
     
  6. The dynamics and regulation of PARP1 and PARP2 in response to DNA damage and during replication
    Zhang H, Zha S
    DNA Repair (Amst). 2024.
     
  7. Mrc1 regulates parental histone segregation and heterochromatin inheritance
    Toda T, Fang Y, Shan CM, Hua X, Kim JK, Tang LC, Jovanovic M, Tong L, Qiao F, Zhang Z, Jia S
    Mol Cell. 2024.
     
  8. Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA
    Hua X, Zhou H, Wu HC, Furnari J, Kotidis CP, Rabadan R, Genkinger JM, Bruce JN, Canoll P, Santella RM, Zhang Z
    Nat Commun. 2024.
     
  9. Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis
    Ahmed A, Kato N, Gautier J
    J Mol Biol. 2024.
     
  10. Romidepsin and Afatinib Abrogate Jak-Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma
    Shih BB, Ma C, Cortes JR, Reglero C, Miller H, Quinn SA, Albero R, Laurent AP, Mackey A, Ferrando AA, Geskin L, Palomero T
    J Invest Dermatol. 2024.
     
  11. Understanding the complexity of p53 in a new era of tumor suppression
    Liu Y, Su Z, Tavana O, Gu W
    Cancer Cell. 2024.
     
  12. An unexpected role for the ketogenic diet in triggering tumor metastasis by modulating BACH1-mediated transcription
    Su Z, Liu Y, Xia Z, Rustgi AK, Gu W
    Sci Adv. 2024.
     
  13. The PCNA-Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance
    Serra-Cardona A, Hua X, McNutt SW, Zhou H, Toda T, Jia S, Chu F, Zhang Z
    Sci Adv. 2024.
     
  14. Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2
    Gan S, Yang WS, Wei L, Zhang Z, Xu RM
    Sci China Life Sci. 2024.
     
  15. TARGET: A phase I/II open-label multicenter study to assess safety and efficacy of fexagratinib in patients with relapsed/refractory FGFR fusion-positive glioma
    Picca A, Di Stefano AL, Savatovsky J, Ducray F, Chinot O, Moyal EC, Augereau P, Le Rhun E, Schmitt Y, Rousseaux N, Yepnang AMM, Estellat C, Charbonneau F, Letourneur Q, Branger DF, Meyronet D, Fardeau C, Mokhtari K, Bielle F, Iavarone A, Sanson M
    Neurooncol Adv. 2024.
     
  16. Systematic analysis of proteome turnover in an organoid model of pancreatic cancer by dSILO
    Ross AB, Gorhe D, Kim JK, Hodapp S, DeVine L, Chan KM, Chio IIC, Jovanovic M, Ayres Pereira M
    Cell Rep Methods. 2024.
     
  17. RuBi-Ruxolitinib: A Photoreleasable Antitumor JAK Inhibitor
    Rafic E, Ma C, Shih BB, Miller H, Yuste R, Palomero T, Etchenique R
    J Am Chem Soc. 2024.
     
  18. Extrachromosomal telomere DNA derived from excessive strand displacements
    Lee J, Lee J, Sohn EJ, Taglialatela A, O'Sullivan RJ, Ciccia A, Min J
    Proc Natl Acad Sci USA. 2024.
     
  19. Deregulated DNA ADP-ribosylation impairs telomere replication
    Wondisford AR, Lee J, Lu R, Schuller M, Groslambert J, Bhargava R, Schamus-Haynes S, Cespedes LC, Opresko PL, Pickett HA, Min J, Ahel I, O'Sullivan RJ
    Nat Struct Mol Biol. 2024.
     
  20. Chromatin compartments at DNA double-stranded breaks
    Min J, Gautier J
    Cell Res. 2024.
     
  21. BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
    Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D
    Cell Rep. 2024.
     
  22. PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
    Yang X, Wang Z, Samovich SN, Kapralov AA, Amoscato AA, Tyurin VA, Dar HH, Li Z, Duan S, Kon N, Chen D, Tycko B, Zhang Z, Jiang X, Bayir H, Stockwell BR, Kagan VE, Gu W
    Cell Metab. 2024.
     
  23. Atypical Fibroxanthoma Treated with a Topical Combination of Imiquimod, Tazarotene, and 5-Fluorouracil
    Nahm WJ, Badiavas EV, Kirsner RS, Boyd CJ, Arthur AA, Bae S, Shen J
    Dermatol Ther (Heidelb). 2024.
     
  24. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance
    Fang Y, Hua X, Shan CM, Toda T, Qiao F, Zhang Z, Jia S
    Genes Dev. 2024.
     
  25. GAS41 modulates ferroptosis by anchoring NRF2 on chromatin
    Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W
    Nat Commun. 2024.
     
  26. SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, Hickman AR, Mao W, Thakar T, Vaitsiankova A, Huang JW, Cuella-Martin R, Hayward SB, Kesner JS, Ghasemzadeh A, Nambiar TS, Ho P, Rialdi A, Hebrard M, Li Y, Gao J, Gopinath S, Adeleke OA, Venters BJ, Drake CG, Baer R, Izar B, Guccione E, Keogh MC, Guerois R, Sun L, Lu C, Califano A, Ciccia A
    Cell. 2024.
     
  27. Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
    Ko EJ, Kim DY, Kim MH, An H, Kim J, Jeong JY, Song KS, Cha HJ
    Int J Mol Sci. 2024.
     
  28. Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA
    Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J
    bioRxiv. 2024.
     
  29. CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue
    Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu S, Chou J, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT
    bioRxiv. 2023.
     
  30. A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling
    Li Y, Shah RB, Sarti S, Belcher AL, Lee BJ, Gorbatenko A, Nemati F, Yu H, Stanley Z, Rahman M, Shao Z, Silva JM, Zha S, Sidi S
    Sci Signal. 2023.
     

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