Institute for Cancer Genetics

Recent Publications

  1. Visualization and quantification of rDNA instabilities in mammalian cells and mouse models
    Zhu X, Jiang W, Wu W, Lee BJ, Menolfi D, Tubbs A, Cupo OM, Malkovskiy E, Nester M, Wang XS, Sims PA, Lin CV, Symington L, Nussenzweig A, McStay B, Zha S
    Nucleic Acids Res. 2026.
     
  2. Activation of T Cell-Intrinsic p53 by Acetylation Elicits Antitumor Immunity to Boost Cancer Immunotherapy
    Yan X, Xu W, Yao H, Wu Z, Ning J, Zhao S, Liu Y, Zhang M, Xu D, Shen Z, Gu W, Wang D
    Cancer Discov. 2026.
     
  3. Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing
    Yu T, Yoon J, Zhu Y, Li A, Lee BJ, Moakley DF, Duan J, Deng Q, Hou F, Yan M, Gennarino VA, Zhang K, Chen L, Zha S, Zhang C
    bioRxiv. 2025.
     
  4. Therapeutic outlooks for Gal-1 and genotoxic agents
    Sohn EJ, Min J
    FEBS J. 2025.
     
  5. Deep Generative AI for Multi-Target Therapeutic Design: Toward Self-Improving Drug Discovery Framework
    Kang SI, Shin JH, Wu BM, Choi HS
    Int J Mol Sci. 2025.
     
  6. The PURB-HOTAIR complex regulates p53-dependent promoter-specific transcriptional activation
    Xia Z, Kon N, Su Z, Yi J, Hua X, Zhou H, Zhang Z, Gu W
    Nat Struct Mol Biol. 2025.
     
  7. Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers
    Lee J, Sohn EJ, Lee J, Cheng AY, Taglialatela A, Ciccia A, Min J
    Nucleic Acids Res. 2025.
     
  8. Weight loss in patients on osimertinib for metastatic EGFR-mutant non-small cell lung cancer
    Chen LN, Ma X, Herzberg B, Henick BS, Biswas AK, Acharyya S, Shu CA
    Oncologist. 2025.
     
  9. p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases
    Liu Y, Stockwell BR, Jiang X, Gu W
    Nat Rev Mol Cell Biol. 2025.
     
  10. Ku limits RNA-induced innate immunity to allow Alu expansion in primates
    Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild-Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S
    Nature. 2025.
     
  11. Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap
    Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Chen C', Paiva M, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT
    Nat Biotechnol. 2025.
     
  12. Dual Role of NRF2 in Pancreatic Precursor Lesions
    Ichimiya S, Ahn SS, Dixon MS, O'Sullivan JP, DeVine LC, Chen A, Yamamoto T, Oda Y, Nakamura M, Chio IIC
    Cancer Res Commun. 2025.
     
  13. Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
    Karri S, Dickinson Q, Li Z, Yu C, Zhang Z
    J Vis Exp. 2025.
     
  14. The replication stress response: Mechanisms and functions
    Ciccia A, Vindigni A
    DNA Repair (Amst). 2025.
     
  15. Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers
    Lee J, Sohn EJ, Lee J, Taglialatela A, Ciccia A, Min J
    bioRxiv. 2025.
     
  16. A new, immunocompetent brain-metastatic mouse model of HER2-positive breast cancer
    Chen L, Chow A, Ma W, Coker C, Gu Y, Canoll P, Kandpal M, Hibshoosh H, Biswas AK, Acharyya S
    Clin Exp Metastasis. 2025.
     
  17. Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia
    Bertulfo K, Perez-Duran P, Miller H, Ma C, Ambesi-Impiombato A, Samon J, Mackey A, Lin WW, Ferrando AA, Palomero T
    Proc Natl Acad Sci USA. 2025.
     
  18. Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma
    Gallitto M, Zhang X, De Los Santos G, Wei HJ, Fernández EC, Duan S, Sedor G, Yoh N, Kokossis D, Angel JC, Wang YF, White E, Kinslow CJ, Berg X, Tomassoni L, Zandkarimi F, Chio IIC, Canoll P, Bruce JN, Feldstein NA, Gartrell RD, Cheng SK, Garvin JH, Zacharoulis S, Wechsler-Reya RJ, Pavisic J, Califano A, Zhang Z, Wu CC
    Neuro Oncol. 2025.
     
  19. Scalable co-sequencing of RNA and DNA from individual nuclei
    Olsen TR, Talla P, Sagatelian RK, Furnari J, Bruce JN, Canoll P, Zha S, Sims PA
    Nat Methods. 2025.
     
  20. XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites
    Lin X, Leung KSK, Wolfe KF, Call N, Bhandari SK, Huang X, Lee BJ, Tomkinson AE, Zha S
    Nucleic Acids Res. 2025.
     
  21. A tale of two strands: Decoding chromatin replication through strand-specific sequencing
    Li Z, Zhang Z
    Mol Cell. 2025.
     
  22. H3K56 acetylation regulates chromatin maturation following DNA replication
    Duan S, Nodelman IM, Zhou H, Tsukiyama T, Bowman GD, Zhang Z
    Nat Commun. 2025.
     
  23. Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis
    Su Z, Liu Y, Wang L, Gu W
    Genes Dis. 2025.
     
  24. Expression profiles of TNF-Alpha and HERV-K Env proteins in multiple types of colon and lung disease
    Ko EJ, Jeong JY, Bae SC, Cha HJ
    Genes Genomics. 2025.
     
  25. Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug-Resistant Cancer via Oxidative Autophagy Inhibition
    Park M, Nam JS, Kim T, Yoon G, Kim S, Lee C, Lee CG, Park S, Bejoymohandas KS, Yang J, Kwon YH, Lee YJ, Seo JK, Min D, Park T, Kwon TH
    Adv Sci (Weinh). 2025.
     
  26. Single-Cell Transcriptomic Analysis of Normal and Malignant B Cells
    Holmes AB, Corinaldesi C, Basso K
    Methods Mol Biol. 2025.
     
  27. Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance
    Corinaldesi C, Holmes AB, Martire G, Tosato A, Rizzato D, Lovisa F, Gallingani I, Shen Q, Ferrone L, Harris M, Davies K, Molinaro L, Mortara U, Dei Tos AP, Ofori K, D'Amore ESG, Chiarle R, Ngan B, Carraro E, Pillon M, Hussein S, Bhagat G, Pizzi M, Mussolin L, Basso K
    Leukemia. 2025.
     
  28. PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression
    Yang X, Gu W
    J Mol Cell Biol. 2024.
     
  29. Ferroptosis as a new tool for tumor suppression through lipid peroxidation
    Yang X, Liu Y, Wang Z, Jin Y, Gu W
    Commun Biol. 2024.
     
  30. UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks
    Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J
    DNA Repair (Amst). 2024.
     

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