Institute for Cancer Genetics

Recent Publications

  1. PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
    Yang X, Wang Z, Samovich SN, Kapralov AA, Amoscato AA, Tyurin VA, Dar HH, Li Z, Duan S, Kon N, Chen D, Tycko B, Zhang Z, Jiang X, Bayir H, Stockwell BR, Kagan VE, Gu W
    Cell Metab. 2024.
     
  2. BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks
    Georgieva D, Wang N, Taglialatela A, Jerabek S, Reczek CR, Lim PX, Sung J, Du Q, Horiguchi M, Jasin M, Ciccia A, Baer R, Egli D
    Cell Rep. 2024.
     
  3. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance
    Fang Y, Hua X, Shan CM, Toda T, Qiao F, Zhang Z, Jia S
    Genes Dev. 2024.
     
  4. GAS41 modulates ferroptosis by anchoring NRF2 on chromatin
    Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W
    Nat Commun. 2024.
     
  5. Atypical Fibroxanthoma Treated with a Topical Combination of Imiquimod, Tazarotene, and 5-Fluorouracil
    Nahm WJ, Badiavas EV, Kirsner RS, Boyd CJ, Arthur AA, Bae S, Shen J
    Dermatol Ther (Heidelb). 2024.
     
  6. Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2
    Gan S, Yang WS, Wei L, Zhang Z, Xu RM
    Sci China Life Sci. 2024.
     
  7. SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, Hickman AR, Mao W, Thakar T, Vaitsiankova A, Huang JW, Cuella-Martin R, Hayward SB, Kesner JS, Ghasemzadeh A, Nambiar TS, Ho P, Rialdi A, Hebrard M, Li Y, Gao J, Gopinath S, Adeleke OA, Venters BJ, Drake CG, Baer R, Izar B, Guccione E, Keogh MC, Guerois R, Sun L, Lu C, Califano A, Ciccia A
    Cell. 2024.
     
  8. Romidepsin and Afatinib Abrogate Jak-Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma
    Shih BB, Ma C, Cortes JR, Reglero C, Miller H, Quinn SA, Albero R, Laurent AP, Mackey A, Ferrando AA, Geskin L, Palomero T
    J Invest Dermatol. 2024.
     
  9. Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells
    Ko EJ, Kim DY, Kim MH, An H, Kim J, Jeong JY, Song KS, Cha HJ
    Int J Mol Sci. 2024.
     
  10. Transcription-Coupled Repair of DNA Interstrand Crosslinks by UVSSA
    Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J
    bioRxiv. 2024.
     
  11. CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue
    Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu S, Chou J, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT
    bioRxiv. 2023.
     
  12. A noncanonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling
    Li Y, Shah RB, Sarti S, Belcher AL, Lee BJ, Gorbatenko A, Nemati F, Yu H, Stanley Z, Rahman M, Shao Z, Silva JM, Zha S, Sidi S
    Sci Signal. 2023.
     
  13. Protocol of CRISPR-Cas9 knockout screens for identifying ferroptosis regulators
    Yang X, Duan S, Li Z, Wang Z, Kon N, Zhang Z, Gu W
    STAR Protoc. 2023.
     
  14. Chromatin compartments at DNA double-stranded breaks
    Min J, Gautier J
    Cell Res. 2023.
     
  15. ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development
    Wu-Baer F, Wong M, Tschoe L, Lin CS, Jiang W, Zha S, Baer R
    Cells. 2023.
     
  16. Introduction to series: Diffuse large B-cell lymphoma
    Smith SM, Pasqualucci L
    Semin Hematol. 2023.
     
  17. Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements
    Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff SP, Zhang Z
    Nature. 2023.
     
  18. Extrachromosomal Telomeres Derived from Excessive Strand Displacements
    Lee J, Lee J, Sohn EJ, Taglialatela A, O'Sullivan RJ, Ciccia A, Min J
    bioRxiv. 2023.
     
  19. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
    Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu XM, Zhou J, Wang D, Gu W, Li D
    Cell Rep. 2023.
     
  20. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism
    Yang X, Wang Z, Zandkarimi F, Liu Y, Duan S, Li Z, Kon N, Zhang Z, Jiang X, Stockwell BR, Gu W
    Cell Metab. 2023.
     
  21. Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner
    Shao Z, Lee BJ, Zhang H, Lin X, Li C, Jiang W, Chirathivat N, Gershik S, Shen MM, Baer R, Zha S
    Proc Natl Acad Sci USA. 2023.
     
  22. Base-editing screens illuminate variant effects in human hematopoiesis
    Vaitsiankova A, Thakar T, Ciccia A
    Cell Rep Methods. 2023.
     
  23. Mechanisms of insertions at a DNA double-strand break
    Min J, Zhao J, Zagelbaum J, Lee J, Takahashi S, Cummings P, Schooley A, Dekker J, Gottesman ME, Rabadan R, Gautier J
    Mol Cell. 2023.
     
  24. The DNA Damage Response and Inflammation in Cancer
    Klapp V, Álvarez-Abril B, Leuzzi G, Kroemer G, Ciccia A, Galluzzi L
    Cancer Discov. 2023.
     
  25. Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
    Schvartzman JM, Forsyth G, Walch H, Chatila W, Taglialatela A, Lee BJ, Zhu X, Gershik S, Cimino FV, Santella A, Menghrajani K, Ciccia A, Koche R, Sánchez-Vega F, Zha S, Thompson CB
    Mol Cell. 2023.
     
  26. Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1
    Yi J, Li H, Chu B, Kon N, Hu X, Hu J, Xiong Y, Kaniskan HU, Jin J, Gu W
    Cell Death Differ. 2023.
     
  27. Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice
    Zhu Y, Jiang W, Lee BJ, Li A, Gershik S, Zha S
    Proc Natl Acad Sci USA. 2023.
     
  28. ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion
    Menolfi D, Lee BJ, Zhang H, Jiang W, Bowen NE, Wang Y, Zhao J, Holmes A, Gershik S, Rabadan R, Kim B, Zha S
    Nat Commun. 2023.
     
  29. The germinal center in the pathogenesis of B cell lymphomas
    Pasqualucci L
    Hematol Oncol. 2023.
     
  30. SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation
    Su H, Cantrell AC, Chen JX, Gu W, Zeng H
    Cells. 2023.
     

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