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Selected Publications
- Tezel G. Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets. Prog Retin Eye Res. 2022;87:100998. PMID: 34348167
- Yang X, Zeng Q, Tezel G. Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma. Neurobiol Dis. 2021;150:105258. PMID: 33434617
- Aydin R, Baris M, Engin CD, Al-Aswad L, Blumberg DM, Cioffi GA, Liebmann JM, Tezel TH, Tezel G. Early localized alterations of the retinal inner plexiform layer in association with visual field worsening in glaucoma patients. PLOS ONE. 2021;16:e0247401. PMID: 33630899
- Tezel G. Multifactorial pathogenic processes of retinal ganglion cell degeneration in glaucoma towards multi-target strategies for broader treatment effects. Special Issue “Retinal Ganglion Cell Neuroprotection: Approaches to the Treatment of Optic Neuropathies”. Cells. 2021;10:1372-1399.PMID: 34199494
- Yang X, Zeng Q, Baris M, Tezel G. Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma. J Neuroinflammation. 2020;17:252. PMID: 32859212
- Tezel G. A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma. Special Issue “Glaucoma: A Neurodegenerative Disease of the Retina and Beyond”. Prog Brain Res. 2020;256:49-77. PMID: 32958215
- Yang X, Zeng Q, Goktas E, Gopal K, Al-Aswad L, Blumberg D, Cioffi GA, Liebmann JM, Suh LH, Trief D, Tezel G. T-lymphocyte subset distribution and activity in patients with glaucoma. Invest Ophthalmol Vis Sci. 2019;60:877-888. PMID: 30821813
- Hondur G, Göktas E, Yang X, Al-Aswad L, Auran JD, Blumberg DM, Cioffi GA, Liebmann JM, Suh LH, Trief, Tezel G. Oxidative stress-related molecular biomarker candidates for glaucoma. Invest Ophthalmol Vis Sci. 2017;58:4078-4088. PMID: 28820925
- Yang X, Hondur G, Tezel G. Antioxidant treatment limits neuroinflammation in glaucoma. Invest Ophthalmol Vis Sci. 2016;57:2344-2354. PMID: 27127934
- Yang X, Hondur G, Li M, Cai J, Klein JB, Kuehn MH, Tezel G. Proteomics analysis of molecular risk factors in the ocular hypertensive human retina. Invest Ophthalmol Vis Sci. 2015;56:5816-5830. PMID: 26348630
- Tezel G. A decade of the proteomics studies of glaucomatous neurodegeneration. Special Issue “Proteomics and the Eye”. Proteomics Clin Appl. 2014;8:154-167. PMID: 24415558
- Tezel G. A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration. Prog Retin Eye Res. 2013;35:18-43. PMID: 23396249
- Tezel G, Yang X, Luo C, Cai J, Powell DW. An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma. Invest Ophthalmol Vis Sci. 2012;53:4220-4233. PMID: 22570341
- Tezel G, Thornton IL, Tong MG, Luo C, Yang X, Cai J, Powell DW, Soltau JB, Liebmann JM, Ritch R. Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma. Invest Ophthalmol Vis Sci. 2012;53:8222-8231. PMID: 23150628
- Yang X, Luo C, Cai J, Powell DW, Yu D, Kuehn MH, Tezel G. Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci. 2011;52:8442-8454. PMID: 21917936
- Luo C, Yang X, Kain AD, Powell DW, Kuehn MH, Tezel G. Glaucomatous tissue stress and the regulation of immune response through the toll-like receptor signaling. Invest Ophthalmol Vis Sci. 2010;51:5697-5707. PMID: 20538986
- Tezel G, Yang X, Luo C, Kain AD, Powell DW, Kuehn MH, Kaplan HJ. Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci. 2010;51:5071-5082. PMID: 20484586
- Tezel G, Yang X, Luo C, Cai J, Kain AD, Powell DW, Kuehn MH, Pierce WM. Hemoglobin expression and regulation in glaucoma: insights into retinal ganglion cell oxygenation. Invest Ophthalmol Vis Sci. 2008;51:907-919. PMID: 19741249
- Yang X, Luo C, Cai J, Pierce WM, Tezel G. Phosphorylation-dependent interaction with 14-3-3 regulates Bad trafficking in retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49:2483-2494. PMID: 18296656
- Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T cell-derived Fas-ligand. J Neurosci. 2008;28:12085-12096. PMID: 19005073
- Tezel G. TNF-α signaling in glaucomatous neurodegeneration. Research series: "Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection”. Prog Brain Res. 2008;173:409-421. PMID: 18929124
- Tezel G, Yang X, Luo C, Peng Y, Sun SL, Sun D. Mechanisms of immune system activation in glaucoma: Oxidative stress stimulates antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci. 2007;48:705-714. PMID: 17251469
- Tezel G, Yang X, Cai J. Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci. 2005;46:3177-3187. PMID: 16123417
- Tezel G, Yang X, Yang J, Wax MB. Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice. Brain Res. 2004;996:202-212. PMID: 14697498
- Tezel G, Yang X. Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci. 2004;45:4049-4059. PMID: 15505055
- Tezel G, Hernandez MR, Wax MB. In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head. Glia. 2001;34:178-189. PMID: 11329180
- Tezel G, Wax MB. Increased production of TNF-α by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in co-cultured retinal ganglion cells. J Neurosci. 2000;20:8693-8700. PMID: 11102475
- Tezel G, Wax MB. The mechanisms of hsp27 antibody-mediated apoptosis in retinal cells. J Neurosci. 2000;20:3552-3562. PMID: 10804196
- Tezel G, Seigel GM, Wax MB. Autoantibodies to small heat shock proteins in glaucoma. Invest Ophthalmol Vis Sci. 1998;39:2277-2287. PMID: 9804136
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