Wei Min, PhD

  • Professor of Chemistry
Profile Headshot


Wei Min, PhD, is a Professor of Chemistry at Columbia University, widely recognized for his work in the field of chemistry and molecular imaging. He holds a PhD in Chemistry from Harvard University and earned his BS in Chemistry from Peking University. With a wealth of experience and expertise, he has made significant contributions to the development of cutting-edge imaging techniques and the exploration of chemical and biological processes.

Academic Appointments

  • Professor of Chemistry

Credentials & Experience

Education & Training

  • PhD, Chemistry, Harvard University
  • BS, Chemistry, Peking University

Honors & Awards

  • 2021: Scientific Achievement Award, the Royal Microscopical Society
  • 2021: Blavatnik National Awards for Young Scientists, Faculty Finalist
  • 2020: Blavatnik National Awards for Young Scientists, Faculty Finalist
  • 2019: Blavatnik National Awards for Young Scientists, Faculty Finalist
  • 2019: Pittsburgh Conference Achievement Award
  • 2018: Analyst Emerging Investigator Lectureship
  • 2017: ACS Early Career Award in Experimental Physical Chemistry
  • 2017: Coblentz Award in Molecular Spectroscopy
  • 2015: Buck-Whitney Award of American Chemical Society
  • 2015: Camille Dreyfus Teacher-Scholar Award
  • 2014: George Fraenkel Fund Award
  • 2013: Alfred P. Sloan Research Fellowship
  • 2012: National Institute of Health (NIH) Director's New Innovator Award
  • 2012: Young Investigator in Analytical and Bioanalytical Science
  • 2012: Blavatnik Awards for Young Scientists of the New York Academy of Sciences, Faculty Finalist
  • 2012: Research Initiatives for Science and Engineering (RISE) Award of Columbia University


Wei Min's research at Columbia University revolves around the development and application of advanced imaging techniques to investigate molecular and cellular processes at unprecedented levels of detail. His work encompasses a wide range of topics, from super-resolution microscopy and vibrational spectroscopy to the study of complex biological systems.

Research Interests

  • Biochemistry and Biophysics
  • Microscopy and Imaging

Selected Publications

  1. C. W. Freudiger*, W. Min*, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang and X. S. Xie. “Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy”, Science, 322, 1857, (2008). *equal contribution.
  2. W. Min, S. Lu, S. Chong, R. Rahul, G. H. Holtom and X. S. Xie. “Imaging chromophores with undetectable fluorescence by simulated emission microscopy”, Nature, 461, 1105, (2009).
  3. L. Wei, Y. Yu, Y. Shen, W. C. Wang* and W. Min*. “Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy”, Proc. Natl. Acad. Sci. USA 110, 11226 (2013). *Co-corresponding authors.
  4. L. Wei, F. Hu, Y. Shen, Z. Chen, Y. Yu, C. Lin, M. Wang and W. Min. “Live-cell imaging with alkyne-tagged small biomolecules by stimulated Raman Scattering”, Nature Methods, 11, 410 (2014).
  5. Z. Chen, D. Paley, L. Wei, A. Weisman, R. Friesner, C. Nuckolls* and W. Min*. “Multicolor live-cell chemical imaging by isotopically edited alkyne vibrational palette”, J. Am. Chem. Soc. 136, 8027 (2014). *Co-corresponding authors.
  6. L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min. “Super-multiplex vibrational imaging”, Nature, 544, 465 (2017).
  7. Y. Shen, Z. Zhao, L. Zhang, L. Shi, S. Shahriar, R. B. Chan, G. Paolo and W. Min. Metabolic activity induces membrane phase separation in endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 114, 13394 (2017).
  8. F. Hu, C. Zeng, R. Long, Y. Miao, L. Wei, Q. Xu and W. Min. Super-multiplexed optical imaging and barcoding with engineered polyynes. Nature Methods, 15, 194 (2018).
  9. L. Shi, C. Zheng, Y. Shen, Z. Chen, E. Silveira, L. Zhang, M. Wei, C. Liu, C. Sena-Tomas, K. Targoff, and W. Min. Optical imaging of metabolic dynamics in animals. Nature Communications, 9, 2995 (2018).
  10. Q. Cheng, L. Wei, Z. Liu, N. Ni, Z. Sang, B. Zhu, W. Xu, L.-Q. Chen, W. Min* and Y. Yang*. “In-operando, three dimensional, and simultaneous visualization of ion depletion and lithium growth by stimulated Raman scattering microscopy”, Nature Communications, 9, 2942 (2018) *Co-corresponding authors.
  11. M. Wei, L. Shi, Y. Shen, Z. Zhao, A. Guzman, L. J. Kaufman, L. Wei and W. Min. Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy. Proc. Natl. Acad. Sci. USA 116, 6608 (2019).
  12. Y. Shen, F. Hu and W. Min. Raman imaging of small biomolecules. Annual Review of Biophysics 48, 347 (2019).
  13. L. Zhang, L. Shi, Y. Shen, Y. Miao, M. Wei, N. Qian, Y. Liu and W. Min. Spectral tracing of deuterium for imaging glucose metabolism. Nature Biomedical Engineering 3, 402 (2019).
  14. H. Xiong, L. Shi, L. Wei, Y. Shen, R. Long, Z. Zhao and W. Min. Stimulated Raman excited fluorescence spectroscopy and imaging. Nature Photonics 13, 412 (2019).
  15. L. Shi, F. Hu and W. Min. Optical mapping of biological water in single live cells by stimulated Raman excited fluorescence microscopy. Nature Communications 10, 4764 (2019).
  16. L. Shi, X. Liu, L. Shi, H. T. Stinson, J. Rowlette, L. J. Kahl, C. R. Evans, C. Zheng, L. E. P. Dietrich and W. Min. Mid-infrared metabolic imaging with vibrational probes, Nature Methods 17, 844 (2020).
  17. Z. Zhao, C. Chen, S. Wei, H. Xiong, F. Hu, Y. Miao, T. Jin and W. Min. Ultra-bright Raman dots for multiplexed optical imaging, Nature Communications 12, 1305 (2021).
  18. H. Xiong, N. Qian, Y. Miao, Z. Zhao, C. Chen and W. Min. Super-resolution vibrational microscopy by stimulated Raman excited fluorescence, Light: Science & Applications 10, 87 (2021).
  19. C. Chen, Z. Zhao, N. Qian, S. Wei, F. Hu and W. Min. Multiplexed live-cell profiling with Raman probes, Nature Communications 12, 3405 (2021).
  20. L. Shi, M. Wei, Y. Miao, N. Qian, L. Shi, R. Singer, R. Benninger and W. Min. One-shot super-multiplexed volumetric imaging of proteins by RADIANT, Nature Biotechnology (2021) in press