Riccardo Dalla-Favera, MD

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Overview

Academic Appointments

  • Percy and Joanne Uris Professor of Clinical Medicine
  • Professor of Pathology & Cell Biology
  • Professor of Microbiology and Immunology (in the Institute for Cancer Genetis and the Herbert Irving Comprehensive Cancer Center)

Administrative Titles

  • Director, Institute for Cancer Genetics

Research

The research program in the Dalla-Favera laboratory is aimed at the identification of the molecular pathogenesis of human B cell malignancies. Functional and structural genomic approaches are used toward the identification of the genetic lesions leading to the transformation of B lymphocytes. The genomic landscape of the tumors is then recapitulated in genetically modified mice in order to construct models for pre-clinical testing of science-based new therapeutic modalities.

Selected Publications

  1. Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
    Bal E, Kumar R, Hadigol M, Holmes AB, Hilton LK, Loh JW, Dreval K, Wong JCH, Vlasevska S, Corinaldesi C, Soni RK, Basso K, Morin RD, Khiabanian H, Pasqualucci L, Dalla-Favera R.
    Nature. 2022
    PMID: 35794478
  2. Tracking Immunoglobulin Repertoire and Transcriptomic Changes in Germinal Center B Cells by Single-Cell Analysis
    Corinaldesi C, Holmes AB, Shen Q, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K.
    Front Immunol. 2022
    PMID: 35095922
  3. Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
    Fangazio M, Ladewig E, Gomez K, Garcia-Ibanez L, Kumar R, Teruya-Feldstein J, Rossi D, Filip I, Pan-Hammarstr├Âm Q, Inghirami G, Boldorini R, Ott G, Staiger AM, Chapuy B, Gaidano G, Bhagat G, Basso K, Rabadan R, Pasqualucci L, Dalla-Favera R.
    Proc Natl Acad Sci U S A. 2021
    PMID: 34050029
  4. Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome
    Holmes AB, Corinaldesi C, Shen Q, Kumar R, Compagno N, Wang Z, Nitzan M, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K
    J Exp Med. 2020.
    PMID: 32603407
  5. Chronic lymphocytic leukaemia: from genetics to treatment
    Bosch F, Dalla-Favera R
    Nat Rev Clin Oncol. 2019.
    PMID: 31278397
  6. Repurposing dasatinib for diffuse large B cell lymphoma
    Scuoppo C, Wang J, Persaud M, Mittan SK, Basso K, Pasqualucci L, Rabadan R, Inghirami G, Grandori C, Bosch F, Dalla-Favera R
    Proc Natl Acad Sci USA. 2019.
    PMID: 31383760
  7. MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis
    Brescia P, Schneider C, Holmes AB, Shen Q, Hussein S, Pasqualucci L, Basso K, Dalla-Favera R
    Cancer Cell. 2018.
    PMID: 30205047
  8. Genetics of diffuse large B-cell lymphoma
    Pasqualucci L, Dalla-Favera R
    Blood. 2018.
    PMID: 29666115, DOI: 10.1182/blood-2017-11-764332
    The molecular pathogenesis of chronic lymphocytic leukaemia
    Fabbri G, Dalla-Favera R
    Nat Rev Cancer. 2016.
    PMID: 26911189
  9. Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
    Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L
    Nat Med. 2015.
    PMID: 26366712
  10. Germinal centres and B cell lymphomagenesis
    Basso K, Dalla-Favera R
    Nat Rev Immunol. 2015.
    PMID: 25712152
  11. MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma
    Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Hussein S, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R
    Nat Immunol. 2013.
    PMID: 23974956
  12. Combined genetic inactivation of ╬▓2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma
    Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R
    Cancer Cell. 2011.
    PMID: 22137796
  13. Analysis of the coding genome of diffuse large B-cell lymphoma
    Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R
    Nat Genet. 2011.
    PMID: 21804550
  14. Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R
    Nature. 2011.
    PMID: 21390126
  15. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma
    Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R
    Cancer Cell. 2010.
    PMID: 21156281
  16. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
    Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R
    Science. 1993.
    PMID: 8235596
  17. Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma
    Gelmann EP, Psallidopoulos MC, Papas TS, Dalla-Favera R
    Nature. 1983.
    PMID: 6419123