Krzysztof Kiryluk, MD

Nephrology
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Overview

Dr. Krzysztof Kiryluk is an Associate Professor of Medicine (with tenure) at Columbia University. He received his medical degree at the Columbia College of Physicians & Surgeons, completed his residency in Internal Medicine at the Massachusetts General Hospital, Harvard University, and Nephrology fellowship training at the NewYork-Presbyterian Hospital, Columbia University. Dr. Kiryluk specializes in the treatment of chronic kidney disease, glomerulonephritis, and inherited kidney disorders.

Dr. Kiryluk is a physician-scientist, and he serves as the Director of Clinical Research in the Division of Nephrology at Columbia University. His research aims to define genetic factors contributing to the risk of kidney disease. Dr. Kiryluk leads several large collaborative national and international genetic studies of glomerular disorders, such as IgA nephropathy, IgA vasculitis, and membranous nephropathy. Some of Dr. Kiryluk’s interests fall at the interface of research and clinical care. For example, he is leading precision medicine studies involving integrated genomic risk assessment with return of genetic results to patients and clinicians. He is also working on the development of new informatics methods to harness the power of “big data” (clinical and molecular) to enhance genetic discovery and improve clinical care of kidney patients.

Dr. Kiryluk has authored multiple publications and is a recipient of several prestigious awards, including the Donald W. Seldin Young Investigator Award from the American Society of Nephrology. He is an active member of the American Society of Clinical Investigation, American Society of Human Genetics, American Society of Nephrology, and International Society of Nephrology. He also serves as an associate editor of Kidney International. His research has been supported by federal grants from the National Institute of Diabetes and Digestive and Kidney Disease, National Human Genome Research Institute, National Center for Advancing Translational Sciences, National Library of Medicine, as well as private foundations.

Areas of Expertise / Conditions Treated

  • Clinical Molecular Genetics
  • Genetic Disorder
  • Glomerular Diseases and Nephrotic Syndrome
  • Glomerulonephritis
  • Hypertension
  • Kidney Disease

Academic Appointments

  • Associate Professor of Medicine (with tenure)

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Male

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Location(s)

1150 St. Nicholas Avenue
Room #413
New York, NY 10032

Insurance Accepted

Affinity Health Plan

  • Essential Plan
  • Medicaid Managed Care

AgeWell

  • Medicare Managed Care
  • Special Needs

Amida Care

  • Special Needs

Cigna

  • EPO
  • Great West (National)
  • HMO
  • Medicare Managed Care
  • POS
  • PPO

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare

Medicare

  • Railroad
  • Traditional Medicare

Multiplan

  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Quality Health Management

  • Quality Health Management

RiverSpring

  • Special Needs

UnitedHealthcare

  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • Oxford Freedom
  • Oxford HMO
  • Oxford Liberty
  • POS
  • PPO

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

World Trade Center Health Plan

  • World Trade Center Health Plan

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Credentials & Experience

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Residency: Massachusetts General Hospital
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Committees, Societies, Councils

· Associate Editor, Kidney International

· American Society of Clinical Investigation

· American Society of Human Genetics

· International Society of Nephrology

· American Society of Nephrology

Board Certifications

  • Nephrology
  • Internal Medicine

Honors & Awards

2021 Donald W. Seldin Young Investigator Award, American Society of Nephrology and American Heart Association

2020 The American Society of Clinical Investigation (ASCI) elected member

2019 The Harold and Golden Lamport Award for Excellence in Clinical Science Research, Columbia University

2017 Ewig Clinical Scholar Award, Columbia University

2017 Innovations in Kidney Education Award, American Society of Nephrology

2015 Herbert Irving Scholar, College of Physicians & Surgeons, Columbia University

2014 Carl W. Gottschalk Research Scholar, American Society of Nephrology

2011 Marc Anthony Zambetti Assistant Professorship, College of Physicians & Surgeons, Columbia University

2009 Young Investigator Award, American Society of Hypertension

2008 Daland Fellow in Clinical Investigation, American Philosophical Society

2006 Patient Oriented Research Scholar, Irving Institute-Mailman School of Public Health

2002 Alpha Omega Alpha

Research

Our laboratory aims to discover genes and genetic mechanisms involved in the pathogenesis of common forms of kidney disease. We focus on the genetic studies of glomerular disorders, including IgA nephropathy, IgA vasculitis, and membranous nephropathy. We are also interested in the effects of ancestry on the risk of kidney disease among worldwide populations. We use genetic and genomic approaches and novel statistical and computational methods to characterize the molecular and clinical consequences of inherited genetic variation. Through our work, we aim to improve the existing diagnostic tools, personalize disease treatments, and lay the basis for development of novel effective therapies.

Research Interests

  • C3 glomerulopathy and genetic regulation of the complement system
  • Genetics of IgA nephropathy and other glomerular disorders
  • Genetics of kidney and urinary tract malformations
  • Personalized genomics of solid organ transplantation

Grants

· RC2-DK116690 NIDDK “Genomics of Glomerular Disease”

· R01-DK105124 NIDDK “Genetics of IgA nephropathy by network-based association studies”

· R01-DK136765 NIDDK “Non-APOL1 genetic factors and kidney transplant outcomes”

· R01-LM013061 NLM “Big Data Methods for Comprehensive Similarity-based Risk Prediction”

· UH3-DK114926 NIDDK “Kidney Precision Medicine Project (KPMP)”

· U01-HG008680 NHGRI “EHR Genomic Risk Assessment and Management for Diverse Populations”

· U01-AI152960 NIAID “MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies”

Selected Publications

  1. Kiryluk K, Moldoveanu Z, Sanders JT, Eison TM, Suzuki H, Julian BA, Novak J, Gharavi AG, Wyatt RJ. (2011) Aberrant glycosylation of IgA1 is inherited in pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis. Kidney International 80:79-87
  2. Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, Eitner F, Snyder HJ, Choi M, Hou P, Scolari F, Izzi C, Gigante M, Gesualdo L, Savoldi S, Amoroso A, Cusi D, Zamboli P, Julian BA, Novak J, Wyatt RJ, Mucha K, Perola M, Kristiansson K, et al. (2012) Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genetics 8(6):e1002765
  3. Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, et al. (2011) Genome wide association study identifies susceptibility loci for IgA nephropathy. Nature Genetics 43:321-327
  4. Papeta N, Kiryluk K, Patel A, Sterken R, Kacak N, Snyder HJ, Imus PH, Mhatre AN, Lawani AK, Julian BA, Wyatt RJ, Novak J, Wyatt CM, Ross MJ, Winston JA, Klotman ME, Cohen DJ, Appel GB, D'Agati VD, Klotman PE, Gharavi AG. (2011) APOL1 genetic variants significantly increase susceptibility to focal segmental glomerulosclerosis and HIV-1 associated nephropathy but not IgA nephropathy in African Americans. JASN 22 (11):1991-6
  5. Sanna-Cherchi S, Kiryluk K, Burgess KE, Bodria M, Sampson MG, Hadley D, Nees SN, Verbitsky M, Perry BJ, Sterken R, Lozanovski VJ, Materna-Kiryluk A, Barlassina C, Kini A, Corbani V, Carrea A, Somenzi D, Murtas C, et al. (2012) Copy-number Disorders Are a Common Cause of Congenital Kidney Malformations. AJHG 91(6):987-97
  6. Kiryluk K, Novak J, Gharavi AG. (2013) Genetics of IgA Nephropathy: Insight from the Genetic Studies. Ann Rev Medicine 64:339-56
  7. Sanna-Cherchi S, Sampogna RV, Papeta N, Burgess KE, Nees SN, Perry BJ, Choi M, Bodria M, Liu Y, Weng PL, Lozanovski VJ, Verbitsky M, Lugani F, Sterken R, Paragas N, Caridi G, Kiryluk K, Al-Awqati Q, D'Agati VD, Drummond IA, Tasic V, Lifton RP, et al. (2013) Mutations in DSTYK and dominant urinary tract malformations. NEJM 369(7):621-9
  8. Materna-Kiryluk A, Kiryluk K, Burgess KE, Bieleninik A, Sanna-Cherchi S, Gharavi AG, Latos-Bielenska A. (2014) The emerging role of genomics in the diagnosis and workup of congenital urinary tract defects: a novel deletion syndrome on chromosome 3q13.31-22.1. Pediatr Nephrol. 29(2):257-67
  9. Kiryluk K and Novak J. (2014) The Genetics and immunobiology of IgA nephropathy. JCI 124(6):2325-32
  10. Kiryluk K, Li Y, Scolari F, Sanna-Cherchi S, Choi M, Verbitsky M, Fasel D, Lata S, Prakash S, Shapiro S, Fischman C, Snyder HJ, Appel G, Izzi C, Viola BF, Dallera N, Del Vecchio L, Barlassina C, Salvi E, Bertinetto FE, Amoroso A, Savoldi S, Rocchietti M, Amore A, Peruzzi L, Coppo R, Salvadori M, Ravani P, Magistroni R, Ghiggeri GM, Caridi G, Bodria M, Lugani F, Allegri L, Delsante M, Maiorana M, Magnano A, Frasca G, Boer E, Boscutti G, Ponticelli C, Mignani R, Marcantoni C, Di Landro D, Santoro D, Pani A, Polci R, Feriozzi S, Chicca S, Galliani M, Gigante M, Gesualdo L, Zamboli P, Battaglia GG, Garozzo M, Maixnerová D, Tesar V, Eitner F, Rauen T, Floege J, Kovacs T, Nagy J, Mucha K, P?czek L, Zaniew M, Mizerska-Wasiak M, Roszkowska-Blaim M, Pawlaczyk K, Gale D, Barratt J, Thibaudin L, Berthoux F, Canaud G, Boland A, Metzger M, Panzer U, Suzuki H, Goto S, Narita I, Caliskan Y, Xie J, Hou P, Chen N, Zhang H, Wyatt RJ, Novak J, Julian BA, Feehally J, Stengel B, Cusi D, Lifton RP, Gharavi AG. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nature Genetics 2014 doi: 10.1038/ng.3118.