Krzysztof Kiryluk, MD

Nephrology

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Overview

Dr. Krzysztof Kiryluk is the Chief of Nephrology and Jay Meltzer M.D. Professor of Medicine with tenure at Columbia University. He received his medical degree at the Columbia College of Physicians & Surgeons, completed his residency in Internal Medicine at the Massachusetts General Hospital, Harvard University, and Nephrology fellowship training at the NewYork-Presbyterian Hospital, Columbia University. Dr. Kiryluk specializes in the treatment of chronic kidney disease, glomerulonephritis, and inherited kidney disorders.

Dr. Kiryluk is a physician-scientist and his research aims to define genetic factors contributing to the risk of kidney disease. He leads several large collaborative national and international genetic studies of immune-mediated glomerular disorders, such as IgA nephropathy, IgA vasculitis, and membranous nephropathy. Some of Dr. Kiryluk's interests fall at the interface of research and clinical care. For example, he is leading precision medicine studies involving integrated genomic risk assessment with return of results to patients and clinicians. He is also working on the development of new informatics methods to harness the power of “big data” (clinical and molecular) to enhance genetic discoveries and improve clinical care for kidney patients.

Dr. Kiryluk has authored over 250 publications and is a recipient of several prestigious awards, including the Donald W. Seldin Young Investigator Award from the American Society of Nephrology and the American Heart Association. He is an active member of the American Society of Clinical Investigation, American Society of Human Genetics, American Society of Nephrology, and International Society of Nephrology. He serves as an associate editor of Kidney International. His research has been supported by federal grants from the National Institute of Diabetes and Digestive and Kidney Disease, National Human Genome Research Institute, National Center for Advancing Translational Sciences, National Library of Medicine, as well as private foundations.

Areas of Expertise / Conditions Treated

  • Clinical Molecular Genetics
  • Genetic Disorder
  • Glomerular Diseases and Nephrotic Syndrome
  • Glomerulonephritis
  • Hypertension
  • Kidney Disease

Academic Appointments

  • Professor of Medicine

Administrative Titles

  • Division Chief, Division of Nephrology
  • Associate Director, Columbia CTSA Precision Medicine Resource

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Male

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Location(s)

CUIMC/Russ Berrie Medical Science Pavilion
1150 St. Nicholas Avenue
Room #413
New York, NY 10032
Phone:
(212) 305-3273
Fax:
(212) 851-5520
Open location in Google Maps

Insurance Accepted

Aetna

  • Aetna Signature Administrators
  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Student Health

Affinity Health Plan

  • Essential Plan
  • Medicaid Managed Care

Amida Care

  • Special Needs

Cigna

  • EPO
  • Great West (National)
  • HMO
  • POS
  • PPO

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross/Blue Shield

  • EPO
  • HMO
  • Medicare Managed Care
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Healthspring (Cigna Medicare)

  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare (National)

  • MagnaCare

Medicare

  • Railroad
  • Traditional Medicare

Multiplan

  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

RiverSpring

  • Special Needs

UnitedHealthcare

  • Compass (Exchange)
  • Empire Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • Oxford Freedom
  • Oxford HMO
  • Oxford Liberty
  • POS
  • PPO

VNSNY CHOICE

  • Medicare Managed Care
  • SelectHealth
  • Special Needs

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

World Trade Center Health Plan

  • World Trade Center Health Plan

*Before your appointment, please contact the doctor’s office or your insurance provider to verify that your insurance is accepted. This list of insurances can change, and the insurance plans listed may not be accepted at all office locations for this provider.

Credentials & Experience

Education & Training

  • MD, Columbia University College of Physicians and Surgeons
  • MS, Biostatistics, Columbia University Mailman School of Public Health
  • Residency: Internal Medicine, Massachusetts General Hospital
  • Fellowship: Nephrology, NewYork-Presbyterian Hospital/Columbia University Medical Center

Committees, Societies, Councils

  • Associate Editor, Kidney International
  • American Society of Clinical Investigation
  • American Society of Human Genetics
  • International Society of Nephrology
  • American Society of Nephrology
  • Dean’s Scientific Research Advisory Committee (SRAC), VP&S

Board Certifications

  • Nephrology
  • Internal Medicine

Honors & Awards

  • Irene and Arthur Fishberg Prize for significant original contributions to internal medicine at VP&S (2025)
  • Jay Meltzer M.D. Endowed Professorship, Vagelos College of Physicians & Surgeons (2024)
  • Donald W. Seldin Young Investigator Award, American Society of Nephrology and American Heart Association (2021)
  • The American Society of Clinical Investigation (ASCI) elected member (2020)
  • The Harold and Golden Lamport Award for Excellence in Clinical Science Research, Columbia University (2019)
  • Ewig Clinical Scholar Award, Columbia University (2017)
  • Innovations in Kidney Education Award, American Society of Nephrology (2017)
  • Herbert Irving Scholar, College of Physicians & Surgeons, Columbia University (2015)
  • Carl W. Gottschalk Research Scholar, American Society of Nephrology (2014)
  • Marc Anthony Zambetti Assistant Professorship, College of Physicians & Surgeons, Columbia University (2011)
  • Young Investigator Award, American Society of Hypertension (2009)
  • Daland Fellow in Clinical Investigation, American Philosophical Society (2008)
  • Patient Oriented Research Scholar, Irving Institute-Mailman School of Public Health (2006)
  • Alpha Omega Alpha (2002)

Research

The Kiryluk Laboratory aims to discover genes and genetic mechanisms involved in the pathogenesis of common forms of kidney disease. We focus on the genetic studies of glomerular disorders, including IgA nephropathy, IgA vasculitis, and membranous nephropathy. We are also interested in the effects of ancestry on the risk of kidney disease among worldwide populations. We use genetic and genomic approaches and novel statistical and computational methods to characterize the molecular and clinical consequences of inherited genetic variation. Through our work, we aim to improve the existing diagnostic tools, personalize disease treatments, and lay the basis for development of novel effective therapies.

Research Interests

  • Complex Traits
  • Electronic Health Records (EHR/EMR)
  • Genetic Studies
  • Genomics
  • Kidney Disease
  • Polygenic Risk Score
  • Precision Medicine

Grants

  • R01-DK144793 NIDDK

“Third generation Polygenic Scores for Kidney Disease”

  • U01-HG013201 NHGRI

"Multi-omics for Health and Disease"

  • U01-DK100876 NIDDK

“CureGN Network

  • RC2-DK116690 NIDDK
    “Genomics of Glomerular Disease”
  • RC2-DK116690 NIDDK
    “Genomics of Glomerular Disease”
  • R01-DK105124 NIDDK
    “Genetics of IgA nephropathy by network-based association studies”
  • R01-DK136765 NIDDK
    “Non-APOL1 genetic factors and kidney transplant outcomes”
  • R01-LM013061 NLM
    “Big Data Methods for Comprehensive Similarity-based Risk Prediction”
  • UH3-DK114926 NIDDK
    “Kidney Precision Medicine Project (KPMP)”
  • U01-HG008680 NHGRI
    “EHR Genomic Risk Assessment and Management for Diverse Populations”
  • U01-AI152960 NIAID
    “MHC and KIR Sequencing and Association Analyses in the iGeneTRAiN Studies”

Selected Publications

  1. Khan A ... Kiryluk K. Polygenic risk affects the penetrance of monogenic kidney disease. Nature Communications 2023;14(1):8318.
  2. Kiryluk K et al. Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. Nature Genetics 2023 Jul;55(7):1091-1105.
  3. Khan A ... Kiryluk K. Genome-wide polygenic score to predict CKD across ancestries. Nature Medicine 2022. 28(7):1412-1420.
  4. Liu L ... Kiryluk K. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. Nature Communications 2022; 13(1):6859.
  5. Shang N ... Kiryluk K. Medical Records-based Kidney Disease Phenotype for Clinical Care and “Big Data” Observational and Genetic Studies. NPJ Digital Medicine 2021; 4(1):70.
  6. Xie J ... Kiryluk K. Genetic Architecture of Membranous Nephropathy and Its Diagnostic Implications. Nature Communications 2020;11(1):1600.
  7. Steers NJ ... Kiryluk K. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. New England Journal of Medicine. 2019;380(20):1918-1928.
  8. Kiryluk K et al. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway PLoS Genetics, 2017; 10;13(2):e1006609.
  9. Kiryluk K et al. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens. Nature Genetics 2014; 46(11):1187-96.

For a complete list of publications, please visit PubMed.gov