Jacqueline Montes, PT, EdD, NCS

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Jacqueline Montes, PT, EdD, NCS obtained her Bachelors degree and physical therapy certification at Hunter College here in New York. She is a licensed physical therapist since 1994 and certified by the American Board of Physical Therapy Specialities as a neurological clinical specialist since 2005. She also received an MA and EdD in Motor Learning and Motor Control from Columbia University's Teachers College. Dr. Montes has worked at the Columbia University Medical Center her entire career first joining the Physical Therapy Department rotating through specialties such as Pulmonary, Orthopedics and Wheelchair Clinic. In 1997 her focus and specialization became the care of acute neurological and neurosurgical patients. In 2003, Dr. Montes joined the multidisciplinary team at the Eleanor and Lou Gehrig MDA ALS Research Center at Columbia University. Her work included evaluating and treating patients with motor neuron disease, as well as coordinating their care at home, rehabilitative services, durable medical equipment and mobility aids.

As a member of a prominent multidisciplinary group of experienced clinical researchers at Columbia University’s SMA Clinical Research Center and the Pediatric Neuromuscular Clinical Research Network (PNCRN) she has had the opportunity to play a role in the development and execution of numerous clinical research studies. She has a particular interest in neuromuscular conditions such as spinal muscular atrophy where her research has been focused. Dr. Montes’ research training includes development of outcome measures, kinematic evaluation of movement, and electromyography to describe weakness and physiologic fatigue during walking. She has also had the opportunity to play a key role in a randomized, controlled, clinical trial of exercise in patients with SMA. Her goals now are focused on a better understanding of disease mechanisms underlying weakness, fatigue and motor impairments, and salutary responsiveness to exercise in SMA and other genetically determined neuromuscular conditions.

Academic Appointments

  • Associate Professor of Rehabilitation and Regenerative Medicine (Physical Therapy) at CUMC

Credentials & Experience

Education & Training

  • BS, Physical Therapy, Hunter College, City University of New York
  • EdD, Motor Learning and Motor Control, Columbia University, Teachers College

Honors & Awards

Neurologic Certified Specialist, American Board of Physical Therapy Specialists
Hunter College, Dean's List, Summa cum Laude, 1994
Leopold Schepp Scholarship 1991-1993


Research Interests:

Pediatric and adult neuromuscular disease, Spinal muscular atrophy, Clinical outcome measures, Gait, Exercise and physical activity, Fatigue

Research Interests

  • exercise
  • fatigue
  • neuromuscular disease
  • spinal muscular atrophy


Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD)
Role: Principal Investigator
Evaluation of Oxidative Capacity and Exercise Tolerance in Ambulatory Patients with Spinal Muscular Atrophy
The proposed research project will focus on the pathophysiological underpinnings of reduced exercise capacity in patients with Spinal Muscular Atrophy (SMA).
Role: Principal Investigator

Muscular Dystrophy Association (MDA) Clinical Trials Travel Grant

Role: Principal Investigator

Evaluation of Oxidative Capacity and Exercise Tolerance in Ambulatory SMA

Goal: This project will examine the pathophysiological underpinnings of reduced exercise capacity in patients with Spinal Muscular Atrophy (SMA). Funds have been requested for the travel not reimbursable through the K award-5 K01HD84690-02.

Selected Publications

Select Publications

1. Montes J, McDermott MP, Mirek E, Mazzone ES, Main M, Glanzman AM, Duong T, Young SD, Salazar R, Pasternak A, Gee R, De Sanctis R, Coratti,G Forcina N, Fanelli L, Ramsey D, Milev E, Civitello M, Pane M, Pera MC, Scoto M, Day JW, Tennekoon G, Finkel R, Darras BT, Muntoni F, De Vivo DC, Mercuri E. Ambulatory Function in Spinal Muscular Atrophy: Age-related Patterns of Progression. PLOS ONE, 2018; https://doi.org/10.1371/journal.pone.0199657.

2. Glanzman AM, Mazzone ES, Young SD, Gee R, Rose K, Mayhew A, Nelson L, Yun C, Alexander K, Darras BT, Zolkipli-Cunningham Z, Tennekoon G, Day JW, Finkel RS, Mercuri E, De Vivo DC, Baldwin R, Bishop KM, Montes J; Evaluator training and reliability for SMA global Nusinersen trials. J Neuromuscul Dis. 2018;5(2):159-166. PMID: 29865090

3. Montes J, McDermott MP, Martens WB, Dunaway S, Glanzman AM, Riley S, Quigley J, Montgomery MJ, Sproule D, Tawil R, Chung WK, Darras BT, De Vivo DC, Kaufmann P, Finkel RS. Six-Minute Walk Test demonstrates motor fatigue in spinal muscular atrophy. Neurology. 2010 Mar 9;74(10):833-8. PubMed PMID: 20211907; PubMed Central PMCID: PMC2839195.

4. Montes J, Dunaway S, Garber CE, Chiriboga CA, De Vivo DC, Rao AK. Leg muscle function and fatigue during walking in spinal muscular atrophy type 3. Muscle Nerve. 2014 Jul;50(1):34-9. PubMed PMID: 24122959.

5. Montes J, Kramer SS, Dunaway S, Montgomery M, Carr B, Rosenberg SK, Sproule DM, Strauss NE, Garber CE, DeVivo DC. A Randomized, Controlled Clinical Trial of Exercise in Patients with Spinal Muscular Atrophy: Methods and Baseline Characteristics. Journal of Neuromuscular Diseases. 2014; 2:151-161. Pub Med PMID: 27858768.

6. Montes J, Zanotto D, Dunaway Young S, Salazar R, De Vivo DC, Agrawal S. Gait Assessment with SoleSound Instrumented Footwear in Spinal Muscular Atrophy. Muscle Nerve. 2017 Aug;56(2):230-236. PMID 27863443

7. Montes J, Kramer S, Dunaway S, Montgomery M, Carr B, Rosenberg SK, Sproule D, Strauss NE, Garber CE, De Vivo DC. Single-Blind, Randomized, Controlled Clinical Trial of Exercise in Ambulatory Spinal Muscular Atrophy: Why are the Results Negative? Journal of Neuromuscular Diseases. 2015, vol. 2, no. 4, pp. 463-470. PubMed PMID: 27858749.

8. Montes J, McIsaac TL, Dunaway S, Kamil-Rosenberg S, Sproule D, Garber CE, De Vivo DC, Rao AK. Falls and spinal muscular atrophy: exploring cause and prevention. Muscle Nerve. 2013 Jan;47(1):118-23. PubMed PMID: 23042039.

9. Dunaway S, Montes J, Garber CE, Carr B, Kramer SS, Kamil-Rosenberg S, Strauss N, Sproule D, De Vivo DC. Performance of the timed "up & go" test in spinal muscular atrophy. Muscle Nerve. 2014 Aug;50(2):273-7. PubMed PMID: 24375426.

10. Montes J, Glanzman AM, Mazzone ES, Martens WB, Dunaway S, Pasternak A, Riley SO, Quigley J, Pandya S, De Vivo DC, Kaufmann P, Chiriboga CA, Finkel RS, Tennekoon GI, Darras BT, Pane M, Mercuri E, McDermott MP. SMA functional composite score: A functional measure in spinal muscular atrophy. Muscle Nerve. 2015 Apr 3;PubMed PMID: 25846132.

11. Mercuri E, Finkel RS, Montes J, Mazzone ES, Sormani MP, Main M, Ramsey D, Mayhew A, Glanzman AM, Dunaway S, Salazar R, Pasternak A, Quigley J, Pane M, Pera MC, Scoto M, Messina S, Sframeli M, Vita GL, D'Amico A, van den Hauwe11 M, Sivo S, Goemans N, Kaufmann P, Darras BT, Bertini E, Muntoni F, De Vivo DC. Patterns of disease progression in ambulant and non-ambulant SMA: implications for clinical trials. Neuromuscular Disorders. Neuromuscul Disord. 2016 Feb;26(2):126-31. Epub 2015 Dec PMID: 26776503

12. Dunaway Young, S, Montes, J, Kramer, S, Marra, JD, Salazar, R, Chiriboga, CA, Garber, C, De Vivo, DC. Six-Minute Walk Test is Reliable and Valid in Spinal Muscular Atrophy. Muscle and Nerve. 2016 Nov;54(5):836-842.
Montes J, Dunaway S, Montgomery MJ, Sproule D, Kaufmann P, De Vivo DC, Rao AK. Fatigue leads to gait changes in spinal muscular atrophy. Muscle Nerve. 2011 Apr;43(4):485-8. PubMed PMID: 21404286.

13. Montes J, Blumenschine M, Dunaway S, Alter AS, Engelstad K, Rao AK, Chiriboga CA, Sproule DM, De Vivo DC. Weakness and fatigue in diverse neuromuscular diseases. J Child Neurol. 2013 Oct;28(10):1277-83. PubMed PMID: 23847297.

14. Montes J, Levy G, Albert S, Kaufmann P, Buchsbaum R, Gordon PH, Mitsumoto H. Development and evaluation of a self-administered version of the ALSFRS-R. Neurology. 2006 Oct 10;67(7):1294-6. PubMed PMID: <17030772.<br />
15. Gordon PH, Cheng B, Montes J, Doorish C, Albert SM, Mitsumoto H. Outcome measures for early phase clinical trials. Amyotroph Lateral Scler. 2007 Oct;8(5):270-3. PubMed PMID: 17852017.

16. Montes J, Cheng B, Diamond B, Doorish C, Mitsumoto H, Gordon PH. The Timed Up and Go test: predicting falls in ALS. Amyotroph Lateral Scler. 2007 Oct;8(5):292-5. PubMed PMID: 17852012.

17. Chen A, Montes J, Mitsumoto H. The role of exercise in amyotrophic lateral sclerosis. Phys Med Rehabil Clin N Am. 2008 Aug;19(3):545-57, ix-x. PubMed PMID: 18625415.

18. Dunaway S, Montes J, Ryan PA, Montgomery M, Sproule DM, De Vivo DC. Spinal muscular atrophy type III: trying to understand subtle functional change over time--a case report. J Child Neurol. 2012 Jun;27(6):779-85. PubMed PMID: 22156787.

19. Blumenschine M, Montes J, Rao AK, Engelstad K, De Vivo DC. Analysis of Gait Disturbance in Glut 1 Deficiency Syndrome. J Child Neurol. 2016 Nov;31(13):1483-1488.

Complete List of Published Work in MyBibliography