Researcher Spotlight: Abdul Hannan, PhD

Abdul Hannan, PhD was born and raised in India, where he earned his Ph.D. in Biochemistry at the University of Hyderabad in 2015. His research focused on the establishment of heterochromatin and gene silencing in Saccharomyces cerevisiae (yeast). He joined Columbia University in 2016 as a postdoctoral research scientist in the lab of Xin Zhang, Ph.D., in the Department of Ophthalmology, where he studied how certain biological signals influence the development of tear glands in mice. In 2024, he joined Dr. Balasubramanian’s lab, applying his expertise in eye development to study congenital glaucoma.

Dr. Hannan recently received his first grant: the 2025 Knights Templar Eye Foundation (KTEF) Career Starter Grant, for his project on “Models and Mechanisms of Pediatric Glaucoma.” Since 1998, KTEF has awarded Career Starter Grants to fewer than 150 institutions nationwide. As one of only 16 recipients in 2025, Dr. Hannan shares insights into his scientific journey and recent accomplishments.

1. What is your role in the Bala Lab?

My primary research focus in Dr. Balasubramanian’s laboratory is to investigate the development of aqueous humor outflow tissues, specifically Schlemm’s canal (SC) and the trabecular meshwork (TM), and their contribution to the pathophysiology of congenital glaucoma. Schlemm’s canal is a circumferential structure in the eye that plays a critical role in maintaining intraocular pressure by facilitating aqueous humor drainage. Understanding the molecular and cellular mechanisms governing SC and TM development and function is essential for advancing our knowledge of congenital glaucoma.

2. Are there any particular mentors who inspired and guided your journey?

Throughout my scientific journey, I have had the privilege of working with several mentors who have each played a significant role in shaping my development as a researcher. I am deeply grateful for their invaluable guidance. My Ph.D. advisor, Dr. Krishnaveni Mishra, profoundly influenced my scientific growth, fostering my critical thinking and experimental rigor. I am also greatly inspired by Prof. Xin Zhang’s meticulous and systematic approach to experimental design, which has significantly shaped my research methodology. Additionally, Dr. Balasubramanian’s infectious enthusiasm and unwavering dedication to science continue to motivate and inspire me.

3. What is the primary focus of your grant, “Models and Mechanisms of Pediatric Glaucoma”?

Pediatric glaucoma patients exhibit impaired SC and TM morphology and function, resulting in reduced aqueous humor outflow and elevated intraocular pressure. Recent studies have identified several genes associated with pediatric glaucoma, with one major causative gene being Cyp1b1. However, the mechanism by which Cyp1b1 disrupts SC and TM development remains unclear. My research aims to elucidate the role of Cyp1b1 in SC and TM development and its mechanistic involvement in pediatric glaucoma.

4. Why did you choose to focus on this topic, and how did you develop the idea for it?

Glaucoma is one of the leading causes of vision loss worldwide, affecting individuals across all age groups. Given the crucial role of vision in perceiving and interacting with our environment, I have long been motivated to study the visual system and the pathologies that affect it. Mutations in Cyp1b1 are frequently observed in pediatric glaucoma patients and are linked to defective SC and TM development. A mouse model with this mutation similarly demonstrates these abnormalities. I proposed that investigating the mechanisms underlying SC and TM loss could pave the way for more effective therapeutic strategies.

5. What were some unique challenges you faced when applying for this grant?

Thanks to the guidance of my mentor, Dr. Balasubramanian, and the availability of preliminary data, I did not face major difficulties while writing the grant. However, the process was still time-consuming and intellectually demanding. One key challenge was effectively articulating the significance of the research alongside the technical details, ensuring that both the scientific merit and the broader impact were clearly conveyed.

6. What advice would you give to other researchers applying for their first grant?

Having received my first scientific grant, I’ve learned the importance of starting the application process several months in advance to allow time for planning, writing, and revisions. Preliminary data, even if limited, can significantly strengthen a proposal by demonstrating its feasibility. Most importantly, it is crucial to clearly communicate the significance and potential impact of the research, often more than a detailed technical methodology alone.

Looking ahead, Dr. Hannan is focused on completing his project while continuing to refine his scientific expertise and technical skills. His ultimate goal is to establish an independent laboratory that will allow him to pursue his passion for discovery. Outside of the lab, Dr. Hannan enjoys spending time in nature, often going on excursions with friends to explore new environments and biodiversity. His curiosity also extends to the therapeutic potential of phytochemicals, and he remains interested in exploring their role in disease treatment should the opportunity arise. With a clear vision and an enduring drive to expand his knowledge, Dr. Hannan continues to make strides both professionally and personally, leaving the door open to exciting possibilities ahead.