The CCTI occupies more than 12,000 square feet of space in both the William Black Building and Vagelos College of Physicians and Surgeons at Columbia University Irving Medical Center. The space is currently fully-equipped for cellular and molecular immunology and in vivo studies.

Core facilities within the CCTI include flow cytometry, a clinical studies core, and a transplantation tissue bank. Additionally, the advanced microscopy facilities of the Departments of Microbiology/Immunology and Dermatology, as well as the imaging core in the Herbert Irving Comprehensive Cancer Center, are all available to CCTI investigators. The histology core of the Naomi Berrie Diabetes Center is also available for the proposed studies.