Research and Staff Opportunities

The lab of Ran Reshef is inviting greatly motivated, creative and experienced individuals with a strong interest in innovative immunology research that is at the interface of transplantation and cancer immunology and will have significant translational potential. Our lab focuses on immune responses after hematopoietic stem-cell transplantation and CAR T cell therapies using pre-clinical models, human biospecimens and early phase clinical trials.

Projects in the lab evolve from our published work (Reshef NEJM 2012, Reshef JCO 2015, Moy Blood 2017, Harle ASH 2020) and are funded by several NIH and Department of Defense grants. The lab is part of the Columbia Center for Translational Immunology that is equipped with state-of-the-art resources including CyTOF, full spectrum flow cytometry (Cytek), 10x genomics platform, humanized mice core and immune monitoring core. We work in close collaboration with computational biologists in the Department of biomedical Engineering and manage a unique biospecimen bank that contains blood and tissue samples from recipients of bone marrow transplants and CAR T cell therapies.

Minimum Qualifications

A strong background in immunology and technical experience are required. Must have a PhD or MD degree.

Apply

Applicants should submit a CV, brief description of accomplishments and goals, and contact information of 3 references to: ran.reshef@columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.

The Columbia Center for Translational Immunology (CCTI) is seeking a highly motivated and talented technician to join our team. The laboratory is looking for a team member who can assist with lab organization and immunological assays. We collaborate closely with renowned scientists and physicians across multiple departments at CUIMC spanning research in cancers, cancer therapy, immunology, autoimmunity, transplantation, inflammation, infectious diseases, and others.

Key responsibilities include: operation, maintenance of research laboratory; preparation of samples and reagents; and assistance in immunological assay development and optimization.

Responsibilities

• Assist in the development of new assays, methods, and reagents
• Runs high-volume ELISA
• Maintain a detailed, up-to-date, and accurate record of samples, reagents, instrument tuning and QC
• Perform routine data processing and assists with data analysis
• Maintain and organize supplies inventory
• Order supplies and prepare service bills
• Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement
• Perform other related duties necessary to the functioning of the laboratory

Minimum Qualifications

• Two years of college or a completed A.A. program with an emphasis on chemistry, biology, physics, or physics
• One year of related experience or equivalent in training and experience

Preferred Qualifications

• Previous experience in lab research, especially working with immunological assays and ELISA

Other Requirements

• The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made
• Successful completion of applicable compliance and systems training requirements
• Participation in the medical surveillance program
• Ability to work with laboratory animals
• Potential bloodborne pathogen exposure

Apply

To apply, email Dr. Emmanuel Zorn: ez2184@cumc.columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.

Position Summary

Primary duties include assisting in the continuous and smooth operation of the laboratory; conducting biological assays to monitor immune responses in patients undergoing transplantation or CAR-T cell therapies; and assisting in mouse bone marrow transplant studies. The technician will learn and implement a variety of techniques including flow cytometry, cell culture, single-cell sequencing and immunohistochemistry.

Responsibilities

• Assist with experiments in cell culture and animal models under supervision.
• Maintain a detailed, up-to-date, and accurate record of samples, reagents, instrument tuning and QC.
• Assist in the development of new assays, methods, and reagents.
• Perform routine data processing and assist with data analysis.
• Order reagents, organize inventory, maintain equipment, and prepare service bills.
• Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement.
• Perform additional related duties as assigned.

Minimum Qualifications

Two years of college or a completed A.A. program with an emphasis in chemistry, biology or physics or a completed animal husbandry program

• One year of related experience, or equivalent in education, training and experience
• Must be detail oriented and possess excellent interpersonal, organizational and communication skills.
• Must be self-motivated, able to multi-task, work independently as well as part of a team, and work well under pressure.
• Proficiency with Microsoft Word, Excel, PowerPoint and data management files required.

Other Requirements

The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made

• Position will involve work with laboratory animals
• Potential bloodborne pathogen exposure
• Participation in the medical surveillance program
• Successful completion of applicable compliance and systems training requirements

Candidates should apply online here.

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.

The Reshef Lab at the Columbia Center for Translational Immunology (CCTI) is looking for a talented, ambitious, and highly motivated individual to work in the exciting field of bone marrow transplantation, CAR-T cell therapy and cancer immunotherapy. This position will support research in translational immunology under the direct supervision of the Principal Investigator and in collaboration with other members of the lab.

Primary responsibilities include developing and conducting biological assays to monitor immune responses in patients undergoing transplantation or CAR-T cell therapies, working with animal transplant models to develop new therapies for graft-versus-host disease, and supporting the smooth operation of the laboratory.

The technician will learn and implement a variety of techniques including advanced flow cytometry, cell culture, single-cell sequencing and immunohistochemistry. A qualified individual will have the opportunity to pursue an independent research project, which they may be able to present and publish.

Responsibilities

• Perform experiments in cell culture and animal models
• Perform data processing and analysis.
• Assist in the development of new assays and methods.
• Maintain a detailed, up-to-date, and accurate record of samples and reagents. Maintain and organize inventory.
• Contribute to building a culture that embraces scientific excellence, integrity, efficiency, teamwork, and continuous learning and improvement.

Minimum Qualifications

• Bachelor's degree in biological sciences, engineering, chemistry, physics, math, computer sciences, or related fields.
• Familiarity and excellent skills with PCR and sterile culture techniques.
• Prior experience with work in a lab environment. Ideal candidates will be quick learners and comfortable with new technologies and have excellent hands-on and organizational skills.
• Attention to detail and quality.
• Skills for problem identification and troubleshooting.
• Excellent interpersonal, organizational and communication skills. Must be able to multi-task, work independently as well as part of a team.

Preferred Qualifications

• Previous experience with immunologic assays, cell culture and flow cytometry. Training will be available for qualified applicants who lack specific experience. 
• Previous experience in mouse models is preferred but not mandatory.

Other Requirements

• The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made
• Position will involve work with laboratory animals
• Potential bloodborne pathogen exposure
• Participation in the medical surveillance program
• Successful completion of applicable compliance and systems training requirements.

Applicants should submit a CV, brief description of accomplishments and goals, and contact information of 3 references to: ran.reshef@columbia.edu

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.

The Columbia Center for Translational Immunology CCTI is looking for a technician to work in the Cellular Immunotherapy Laboratory on the T cell responses in the context of viral infections (including COVID-19) and cell-based immunotherapy of cancer.

The technician will work with PIs and post-doctoral fellows but will be expected to take on supervised projects and responsibility for sample processing, tissue cultures and assays. These will be rewarded with ownership of projects as appropriate.

Responsibilities

• Performing assays and prepare solutions according to detailed instructions
• Set up equipment for experiments, maintain cell cultures and perform functional studies using flow cytometry and other techniques
• Carry out fully planned experiments and keep records of results
• Assist with collection, processing, and cryopreservation of samples for experimental or diagnostic purpose
• Order and maintain laboratory supplies
• Perform other related duties as assigned or necessary to the functioning of the laboratory and research

Minimum Qualifications

• Bachelor's degree in chemistry, biology or physics or related science or equivalent in education, training and experience
• Ability to perform work in a neat and orderly manner in accordance with safety regulations
• Ability to organize experiments in standard form and record data in a scientific notebook
• Ability to learn and adapt to new techniques

Preferred Qualifications

• Knowledge of chemistry, biology or physics and various related laboratory procedures and techniques
• Knowledge of experimental materials and standardization
• Exposure to experimental procedures, laboratory equipment and/or working with animals
• Familiarity with computerized operations

Other Requirements

• The candidate selected for this position is required to undergo a drug screening test prior to a final offer of employment being made
• Successful completion of applicable compliance and systems training requirements
• Participation in the medical surveillance program
• Ability to work with laboratory animals
• Potential bloodborne pathogen exposure.

Apply

To apply, email Dr. Pawel Muranski: pjm2170@cumc.columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.

The Postdoctoral Research Fellow candidate for the large animal xenotransplant immunology and surgery laboratory (Nowak Lab) should have completed an MD and/or PhD in a relevant field, such as immunology.  While not required, it is desirable for the candidate to have at least 2 years of clinical experience in a surgical training program.  Experience in non-surgical clinical fields will also make candidates eligible for this position, including candidates with no surgical experience.  The primary responsibility of the fellow will be overseeing all clinical care of the large animals involved in our studies (pigs and nonhuman primates), which includes pre-and post-operative care.  The fellow will also be involved in all operations on the large animals, including access and transplant surgery.  The fellow will be responsible for the conduct, interpretation, and presentation of all relevant immunological data, including but not limited to flow cytometry, PCR, in-vitro assays like MLR and ELISPOT and immunohistochemistry.  The fellow will participate in supervision of several lab and vet technicians and ensure the proper conduct of the experiments being completed.  Candidates without clinical experience will focus less on large animal surgery and more on studies assessing the mechanisms of transplant tolerance in our large animal models.  We expect exposure of the fellow to a multidisciplinary approach and dedication to continuous learning, to develop outstanding personal and professional skills.

Apply

To apply, email Dr. Greg Nowak: gn2356@cumc.columbia.edu

Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.