Biochemistry, Biophysics, and Structural Biology
The Biochemistry, Biophysics, and Structural Biology PhD track in the Biomedical Life Sciences Program applies physical principles and quantitative approaches to reveal how biomolecules fold, interact, and drive cellular physiology, integrating experimental, theoretical, and computational methods. Evolving from Columbia's longstanding strengths in molecular and cellular biophysics, structural biology, and physiology, the track trains students to determine biomolecular structures and dynamics in their native environments and to build predictive, structure-based models of cellular function and disease.
Course Work
Common Program Course Work
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Program Course 1 |
Molecules to Life I (4 credits) |
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Program Course 2 |
Bytes to Biology I (4 credits)
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Program Course 3 |
Molecules to Life II (4 credits) |
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RCR |
Track Specific Coursework
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Track Course 1 |
Molecular Biophysics (BCHMGU4250) |
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Track Course 2 |
Slate: NMR Spect. & Macromol (G6270); CryoEM (BCHM G6400); Bytes to Biology II, Biophysical Chemistry I (BIOC GU4323) OR Biophysical Chemistry II (BIOC GU4324) |
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Track Course 3 |
Any full-term graduate course at Columbia approved by the DGS |
Works in Progress
BMB Seminar & Research In Progress, Instructors: Eric Greene, Sam Sternberg
Skills & Competencies
VIBRE programs require PhD candidates to demonstrate proficiency in the following key scientific skills: Coding, Statistics, Science Writing, Presentation Skills, and Literature Review & Critical Appraisal. The following will allow competencies to be met:
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Coding |
Orientation-based session + Bytes to Biology I |
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Statistics |
Orientation-based session + Bytes to Biology I |
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Science Writing |
NIH/NSF grantwriting course or other DGS approved course |
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Presentation Skills |
BMB Seminar & Research In Progress, Instructors: Eric Greene, Sam Sternberg |
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Literature Review & Critical Appraisal |
"Reading Like a Reviewer" Nano Course, Instructors: Lena Steckelberg & Mimi Ho (1 credit) and 1 credit from another course, e.g., Bytes to Biology II or CryoEM. |
Other Curricular Requirements
- Orientation & Boot Camp – These programs offer students a comprehensive introduction to the Columbia University community and the VIBRE PhD Pathway.
- Advising – Students regularly meet with faculty mentors and program advisors to guide their academic and research decisions, address core research skills, and discuss expectations and needs.
- Research Rotations—During their first year, students complete at least three research rotations, each lasting approximately three months, in the labs of their training faculty. Students select rotations based on their interests. These experiences help them explore potential dissertation mentors while expanding both their practical skills and theoretical understanding in different areas of research.
- First-Year Affiliation and Track Specialization – Students are affiliated with a track of interest during their first year, with formal selection of a program track occurring at the end of the year.
