Basic Science Research

The Department of Urology’s physicians and scientists are actively involved in basic science laboratory research that involves all areas of urology. Current studies include investigating:

  • The molecular contexts of tumors with the aims of identifying the tumor’s drug responsiveness, drug efficacy and resistance
  • The development of technologies for model generation, including functional genomics and proteomics approach
  • The coordination of efforts among a research consortium to promote the effective use of genetically engineered mouse models for prevention research
  • Preclinical studies of intravesical therapy for bladder cancer
  • Investigating the mechanisms of metastasis to study cancer malignancy
  • Urothelial development and regeneration
  • The resistance of prostate cancer
  • Non-muscle invasive transitional bladder cancer


Cory Abate-Shen, PhD, works in the lab with a researcher.

Cory Abate-Shen, PhD

Dr. Abate-Shen’s research focuses on the molecular mechanisms of cancer development. She has a long-standing commitment to the generation of mouse models of cancer and their effective use for translational research.

Visit the Abate-Shen Lab

Michael M. Shen, PhD, reviews a research image with two lab members.

Michael M. Shen, PhD

The Shen laboratory investigates the molecular mechanisms of mammalian development and cancer using in vivo analyses of genetically-engineered mouse models.

Visit the Shen Lab

Cathy Mendelsohn, PhD

Cathy Mendelsohn, PhD

Dr. Mendelsohn’s lab uses mouse models to elucidate genetic and cellular events important for lower urinary tract development, homeostasis, and regeneration.

Visit the Mendelsohn Lab at the Columbia University Center for Benign Urology