Basic Science Research
The Department of Urology’s physicians and scientists are actively involved in basic science laboratory research that involves all areas of urology. Current studies include investigating:
- The molecular contexts of tumors with the aims of identifying the tumor’s drug responsiveness, drug efficacy and resistance
- The development of technologies for model generation, including functional genomics and proteomics approach
- The coordination of efforts among a research consortium to promote the effective use of genetically engineered mouse models for prevention research
- Preclinical studies of intravesical therapy for bladder cancer
- Investigating the mechanisms of metastasis to study cancer malignancy
- Urothelial development and regeneration
- The resistance of prostate cancer
- Non-muscle invasive transitional bladder cancer
Cory Abate-Shen, PhD
Dr. Abate-Shen’s research focuses on the molecular mechanisms of cancer development. She has a long-standing commitment to the generation of mouse models of cancer and their effective use for translational research.
Michael M. Shen, PhD
The Shen laboratory investigates the molecular mechanisms of mammalian development and cancer using in vivo analyses of genetically-engineered mouse models.
Cathy Mendelsohn, PhD
Dr. Mendelsohn’s lab uses mouse models to elucidate genetic and cellular events important for lower urinary tract development, homeostasis, and regeneration.