Kiryluk Lab

POLYGENES

Polish Kidney Genetics Network (POLYGENES) is a collaborative network of Polish nephrologists, pediatricians, and geneticists that aims to advance genetics studies of Polish patients affected by rare inherited forms of kidney disease. The POLYGENES network represents a collaborative effort between the Division of Nephrology at Columbia University in New York and the Polish Registry of Congenital Malformations (PRCM) in the Department of Genetics at Poznań University of Medical Sciences, Poland and The Center of Medical Genetics GENESIS, Poznań, Poland. The network includes a large number of clinical field centers across Poland.

Investigators

Columbia University

Division of Nephrology, Department of Medicine, New York, USA

Krzysztof Kiryluk, MD, MS

Ali G. Gharavi, MD

Polish Registry of Congenital Malformations (PRCM)

Department of Medical Genetics, Poznań University of Medical Sciences, Poznań, Poland
Prof. Anna Latos-Bieleńska, MD, PhD
Anna Materna-Kiryluk, MD, PhD

 

Eligibility

Individuals of all ages, ethnicities, and stages of chronic kidney disease are eligible to participate in our genetic studies. The POLYGENES network prioritizes recruitment of patients carrying the following diagnoses:

Glomerular Disorders (require kidney biopsy except for Henoch-Schönlein Purpura)

  • IgA nephropathy
  • Henoch-Schönlein Purpura (with and without nephritis)
  • Membranous Nephropathy
  • Focal Segmental Glomerulosclerosis
  • Minimal Change Disease
  • C3 Glomerulonephropathy
  • Other forms of glomerular disease with positive family history

Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)

  • Renal agenesis, unilateral or bilateral
  • Renal hypoplasia, unilateral or bilateral
  • Renal dysplasia, unilateral or bilateral
  • Multicystic dysplastic kidney, unilateral or bilateral
  • Doubled kidney, ureter, pelvis or entire collecting system
  • Horseshoe kidney and ectopic kidney
  • Ureteropelvic junction obstruction (UPJO)
  • Vesico-ureteral reflux (VUR)
  • Posterior urethral valves (PUV)
  • Hypospadias and epispadias
  • Other syndromic and familial forms of CAKUT

 

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