Kiryluk Lab

CureGN

The CureGN Study is a longitudinal multicenter cohort study of glomerular disease patients funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health (NIH). The CureGN project aims to recruit and follow 2,400 children and adults with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), and IgA nephropathy (IgAN). Participants will be followed longitudinally to better understand the causes of disease, response to therapy, and disease progression, with the ultimate objective of finding a cure for glomerulonephropathy. Columbia University is one of the four participating clinical centers. The network supports multidisciplinary collaborative research, early phase testing of novel therapies, and effective public-private-patient advocate partnerships.

Inclusion Criteria

This study will accept all ages diagnosed with MCD, FSGS, MN, or IgAN on a first diagnostic kidney biopsy.

  • Diagnosis of MCD, FSGS, MN, or IgAN on first diagnostic kidney biopsy, as per specified pathology definitions
  • First diagnostic kidney biopsy within 5 years of study enrollment
  • Access to first kidney biopsy report and/or slides
  • All ages
  • Willingness to comply with study requirements, including intention to fully participate in protocol-specified follow-up at a clinical study site
  • Informed consent and, where age appropriate, informed assent

Exclusion Criteria

  • ESKD, defined as chronic dialysis or kidney transplant
  • Institutionalized patient
  • Solid organ or bone marrow transplant recipient at time of first kidney biopsy
  • Diagnosis of any of the following at the time of first diagnostic kidney biopsy:
    • Diabetes mellitus
    • Systemic lupus erythematosus
    • HIV infection
    • Active malignancy, except for non-melanoma skin cancer
    • Active Hepatitis B or C infection, defined as positive viral load

More detailed eligibility criteria will be verified by our CureGN team.

If you are a patient and would like to participate in the CureGN study, please contact our clinical coordinator to schedule an evaluation.

Victoria Kolupaeva, PhD

Columbia University, College of Physicians and Surgeons
Department of Medicine, Division of Nephrology
Presbyterian Hospital Building
622 West 168th Street, 8th Floor, #PH875M
New York, NY 10032
Tel 212-851-5180
vk2446@cumc.columbia.edu

For more information, please visit curegn.org and our brochure.

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