Systems Biology

The Systems Biology PhD track in the Biomedical Life Sciences Program is designed to train students to analyze and model the complex networks that drive biological systems at molecular, cellular, and organismal scales. Integrating high-dimensional data, advanced computation, and AI-driven modeling, the track equips students to transform big data into mechanistic insights and predictive models that inform fundamental biology, therapeutic development, and personalized medicine.

Course Work 

Common Program Course Work 

Program Course 1

Molecules to Life I (4 credits)

Program Course 2

Bytes to Biology I (4 credits)

 

Program Course 3

Bytes to Biology II (4 credits)

RCR

Responsible Conduct of Research and Related Policy Issues

Track Specific Coursework 

Track Course 1

Single Cell and Functional Genomics

Track Course 2

Approved Systems Biology (Elective)

Track Course 3

Approved Systems Biology (Elective)

Works in Progress

SysBio WIP (Year 3 start) Program Lead:  Sara Zaccara

Skills & Competencies 

VIBRE programs require PhD candidates to demonstrate proficiency in the following key scientific skills: Coding, Statistics, Science Writing, Presentation Skills, and Literature Review & Critical Appraisal. The following will allow competencies to be met:

Coding

Orientation-based session + Bytes to Biology I

Statistics

Orientation-based session + Bytes to Biology I

Science Writing

NIH/NSF grantwriting course or other DGS approved course

Presentation Skills

CMBS Seminars I and II (Years 1 and 2)

Literature Review & Critical Appraisal

Bytes to Biology I,  Bytes to Biology II, Single Cell & Funtional Genomics (all provide 1 credit each) 

Other Curricular Requirements 

  • Orientation & Boot Camp – These programs offer students a comprehensive introduction to the Columbia University community and the VIBRE PhD Pathway.
  • Advising – Students regularly meet with faculty mentors and program advisors to guide their academic and research decisions, address core research skills, and discuss expectations and needs.
  • Research Rotations – During their first year, students complete at least three research rotations, each lasting about three months, in the labs of training faculty. Students select rotations based on their interests. These experiences help them explore potential dissertation mentors while expanding both their practical skills and theoretical understanding in different areas of research.  
  • First-Year Affiliation and Track Specialization – Students are affiliated with a track of interest during their first year, with formal selection of a program track occurring at the end of the first year.

Director of Graduate Studies

  • Chaolin Zhang, PhD

    • Professor of Systems Biology and Biochemistry and Molecular Biophysics (in the Motor Neuron Center)
    Profile Headshot
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