Systems Biology
The Systems Biology PhD track in the Biomedical Life Sciences Program is designed to train students to analyze and model the complex networks that drive biological systems at molecular, cellular, and organismal scales. Integrating high-dimensional data, advanced computation, and AI-driven modeling, the track equips students to transform big data into mechanistic insights and predictive models that inform fundamental biology, therapeutic development, and personalized medicine.
Course Work
Common Program Course Work
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Program Course 1 |
Molecules to Life I (4 credits) |
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Program Course 2 |
Bytes to Biology I (4 credits)
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Program Course 3 |
Bytes to Biology II (4 credits) |
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RCR |
Track Specific Coursework
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Track Course 1 |
Single Cell and Functional Genomics |
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Track Course 2 |
Approved Systems Biology (Elective) |
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Track Course 3 |
Approved Systems Biology (Elective) |
Works in Progress
SysBio WIP (Year 3 start) Program Lead: Sara Zaccara
Skills & Competencies
VIBRE programs require PhD candidates to demonstrate proficiency in the following key scientific skills: Coding, Statistics, Science Writing, Presentation Skills, and Literature Review & Critical Appraisal. The following will allow competencies to be met:
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Coding |
Orientation-based session + Bytes to Biology I |
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Statistics |
Orientation-based session + Bytes to Biology I |
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Science Writing |
NIH/NSF grantwriting course or other DGS approved course |
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Presentation Skills |
CMBS Seminars I and II (Years 1 and 2) |
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Literature Review & Critical Appraisal |
Bytes to Biology I, Bytes to Biology II, Single Cell & Funtional Genomics (all provide 1 credit each) |
Other Curricular Requirements
- Orientation & Boot Camp – These programs offer students a comprehensive introduction to the Columbia University community and the VIBRE PhD Pathway.
- Advising – Students regularly meet with faculty mentors and program advisors to guide their academic and research decisions, address core research skills, and discuss expectations and needs.
- Research Rotations – During their first year, students complete at least three research rotations, each lasting about three months, in the labs of training faculty. Students select rotations based on their interests. These experiences help them explore potential dissertation mentors while expanding both their practical skills and theoretical understanding in different areas of research.
- First-Year Affiliation and Track Specialization – Students are affiliated with a track of interest during their first year, with formal selection of a program track occurring at the end of the first year.
Director of Graduate Studies
Chaolin Zhang, PhD
- Professor of Systems Biology and Biochemistry and Molecular Biophysics (in the Motor Neuron Center)

