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Verge Genomics Announces a Multi-Institution Collaboration with Columbia University, MGH, USC, and University of Michigan To Advance ALS Research

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Verge Genomics

Verge Genomics, a drug discovery company utilizing genomic data for neuroscience therapeutics, has established a multi-institution industry-academic collaboration with four top universities.
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels Into Irreversible Hydrogels Impairs RNP Granule Function

Source:

Neuron

The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial.

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Research
ALS-Associated Mutant FUS Induces Selective Motor Neuron Degeneration Through Toxic Gain of Function

Source:

Nature Communications

Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most aggressive, juvenile-onset forms of the disease.

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Research
The C9ORF72 GGGGCC Expansion Forms RNA G-Quadruplex Inclusions and Sequesters hnRNP H To Disrupt Splicing in ALS Patient Brains

Source:

eLife

An expanded GGGGCC hexanucleotide in C9ORF72 (C9) is the most frequent known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Augmenting the SMN Protein To Treat Infantile Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a common and oft-fatal pediatric neuromuscular disorder caused by insufficient SMN protein.

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Research
The Ubiquitination of PINK1 Is Restricted To Its Mature 52-kDa Form

Along with Parkin, PINK1 plays a critical role in maintaining mitochondrial quality control.

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Research

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Motor Neuron Center

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New ALS Gene and Signaling Pathways Identified

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A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency

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ALS Association and Target ALS to Expand Tissue Core for ALS Research

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Role of Primary Afferents in the Developmental Regulation of Motor Axon Synapse Numbers on Renshaw Cells

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Latest News

Verge Genomics Announces a Multi-Institution Collaboration with Columbia University, MGH, USC, and University of Michigan To Advance ALS Research

Source:

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels Into Irreversible Hydrogels Impairs RNP Granule Function

Source:

ALS-Associated Mutant FUS Induces Selective Motor Neuron Degeneration Through Toxic Gain of Function

Source:

The C9ORF72 GGGGCC Expansion Forms RNA G-Quadruplex Inclusions and Sequesters hnRNP H To Disrupt Splicing in ALS Patient Brains

Source:

Augmenting the SMN Protein To Treat Infantile Spinal Muscular Atrophy

The Ubiquitination of PINK1 Is Restricted To Its Mature 52-kDa Form

Columbia University Irving Medical Center

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