The COMBO study tracks mothers and children across multiple health domains. Below is a snapshot of our enrollment totals, the follow-up activities completed so far, and what we measure. (Data as of 2/26/2026)
Enrollment Totals
Site
|
Enrolled
|
Alabama
|
87
|
New York
|
1.373
|
Utah
|
243
|
Total
|
1,703
|
Surveys Total Completed
Timepoint
|
Amount
|
2 months
|
756
|
4 months
|
895
|
6 months
|
877
|
9 months
|
554
|
18 months
|
697
|
24 months
|
744
|
36 months
|
Child
|
709
|
Maternal
|
640
|
48 months
|
Child
|
590
|
Maternal
|
531
|
Ambulatory Mood Assessment Survey
Timepoint
|
Completed
|
Prenatal
|
8
|
0 – 1 month
|
13
|
1 – 3 months
|
26
|
3 –5 months
|
28
|
Visits (Home & Video) Totals
Timepoint
|
Measures
|
Completed
|
4 months
|
Early Relational Health (ERH) & maternal sensitivity, still face/mask paradigm
|
606
|
9 months - Visit 1
|
Maternal cognition
|
650
|
9 months - Visit 2
|
ERH, child development
|
636
|
24 months - Visit 1
|
Child development
|
469
|
24 months - Visit 2
|
ERH
|
442
|
36 months - Visit 1
|
ERH, theory of mind, inhibitory control, grit, temperament
|
418
|
36 months - Visit 2
|
ERH, theory of mind, inhibitory control, emotion matching, emotion regulation,
developmental milestones, nutrition
|
380
|
36 months - Visit 3
|
Mealtime observation
|
353
|
48 months - Visit 1
|
ERH, infantile amnesia, book reading, frustration, cooperation
|
475
|
48 months - Visit 2
|
Memory
|
423
|
48 months - Visit 3
|
Language
|
20
|
Other Measures
Physiological & Neuroimaging
|
MRI
|
Mom: 162 completed
|
Baby: 79 completed
|
Dyad: 77 completed
|
Electrophysiology: 4 months (in person)
|
39
|
Biospecimens: Cord blood, placental tissue, maternal blood
|
78 completed
|
Infant Stool Sample: Birth
|
23 completed
|
Behavioral & Sensory
|
Smell tests: 2 months
|
457 completed
|
Sleep Actiography: 18–24 months
|
61 completed
|
Socialization Goals Inventory (SGI) Interview: 8–12 months
|
85 completed
|
Strange Situation Procedure: 12–18 months
|
In Office: 23
|
Remote: 24
|
Qualitative & Psychosocial
|
Qualitative Interviews (NOSI)
|
64 completed
|
