The COMBO study tracks mothers and children across multiple health domains. Below is a snapshot of our enrollment totals, the follow-up activities completed so far, and what we measure. (Data as of March, 2026)
Enrollment Totals
Site
|
Enrolled
|
Alabama
|
87
|
New York
|
1.373
|
Utah
|
243
|
Total
|
1,703
|
Surveys Total Completed
Timepoint
|
Completed
|
2 month
|
756 (52%)
|
4 month
|
895 (57%)
|
6 month
|
877 (51%)
|
9 month
|
554 (44%)
|
18 month
|
720 (48%)
|
24 month
|
756 (54%)
|
36 month
|
Child
|
711 (58%)
|
Maternal
|
644 (89%)
|
48 month
|
Child
|
597 (51%)
|
Maternal
|
534 (89%)
|
Ambulatory Mood Assessment Survey
Timepoint
|
Completed
|
0 – 1 month
|
13 (21%)
|
1 – 3 month
|
26 (21%)
|
3 –5 month
|
28 (21%)
|
Visits (Home & Video) Totals
Timepoint
|
Measures
|
Completed
|
4 month
|
Early Relational Health (ERH) & maternal sensitivity, still face/mask paradigm
|
606 (47%)
|
9 month - Visit 1
|
Maternal cognition
|
650 (54%)
|
9 month - Visit 2
|
ERH, child development
|
636 (53%)
|
24 month - Visit 1
|
Child development
|
475 (39%)
|
24 month - Visit 2
|
ERH
|
447 (37%)
|
36 month - Visit 1
|
ERH, theory of mind, inhibitory control, grit, temperament
|
426 (40%)
|
36 month - Visit 2
|
ERH, theory of mind, inhibitory control, emotion matching, emotion regulation,
developmental milestones, nutrition
|
382 (36%)
|
36 month - Visit 3
|
Mealtime observation
|
355 (33%)
|
48 month - Visit 1
|
ERH, infantile amnesia, book reading, frustration, cooperation
|
497 (51%)
|
48 month - Visit 2
|
Memory
|
438 (45%)
|
48 months - Visit 3
|
Language
|
20 (11%)
|
Other Measures
Physiological & Neuroimaging
|
MRI
|
Mom: 162 completed
|
Baby: 79 completed
|
Dyad: 77 completed
|
Electrophysiology: 4 months (in person)
|
39
|
Biospecimens: Cord blood, placental tissue, maternal blood
|
78 completed
|
Infant Stool Sample: Birth
|
23 completed
|
Behavioral & Sensory
|
Smell tests: 2 months
|
457 completed
|
Sleep Actiography: 18–24 months
|
61 completed
|
Socialization Goals Inventory (SGI) Interview: 8–12 months
|
85 completed
|
Strange Situation Procedure: 12–18 months
|
In Office: 23
|
Remote: 24
|
Qualitative & Psychosocial
|
Qualitative Interviews (NOSI)
|
64 completed
|
