The COMBO study tracks mothers and children across multiple health domains. Below is a snapshot of our enrollment totals, the follow-up activities completed so far, and what we measure. (Data as of June, 2026)
Enrollment Totals
Site
|
Enrolled
|
Alabama
|
87
|
New York
|
1.373
|
Utah
|
243
|
Total
|
1,703
|
Demographics
Category
|
Caregiver
|
Child
|
Age at enrollment (years) /
Gestational ageat birth (weeks)
|
Mean: 33
Min. 18
Max. 53
|
Mean: 39
Min. 24
Max. 43
Preterm: 9.8%
|
Race
|
Asian: 6.8%
Black: 19.7%
Native American: 2.1%
Pacific Islander: 1.3%
White: 50.9%
Other/More than one: 13.6%
Don’t know: 5.6%
|
—
|
Demographics
|
Hispanic: 51.4%
Born in the US: 67.9%
English Speaking: 79.3%
Partnered/Married: 68.7%
Public Insurance: 50.5%
|
Male: 51.7%
First Child: 45.6%
|
Education
|
Less than HS: 5.0%
JS/GED: 12.6%
Trade School/Partial College/
2-Year Degree: 22.0%
4-Year Degreee: 26.6%
Graduate Degree: 33.2%
Other/Unknown: 0.6%
|
—
|
Surveys Total Completed
Timepoint
|
Completed
|
2 month
|
756 (52%)
|
4 month
|
895 (57%)
|
6 month
|
877 (51%)
|
9 month
|
554 (44%)
|
18 month
|
742 (48%)
|
24 month
|
791 (55%)
|
36 month
|
Child
|
721 (58%)
|
Maternal
|
650 (89%)
|
48 month
|
Child
|
597 (51%)
|
Maternal
|
546 (89%)
|
Visits (Home & Video) Totals
Timepoint
|
Measures
|
Completed
|
4 month
|
Early Relational Health (ERH) & maternal sensitivity, still face/mask paradigm
|
606 (47%)
|
9 month - Visit 1
|
Maternal cognition
|
658 (55%)
|
9 month - Visit 2
|
ERH, child development
|
644 (54%)
|
24 month - Visit 1
|
Child development
|
484 (39%)
|
24 month - Visit 2
|
ERH
|
453 (37%)
|
36 month - Visit 1
|
ERH, theory of mind, inhibitory control, grit, temperament
|
436 (40%)
|
36 month - Visit 2
|
ERH, theory of mind, inhibitory control, emotion matching, emotion regulation,
developmental milestones, nutrition
|
396 (36%)
|
36 month - Visit 3
|
Mealtime observation
|
369 (34%)
|
48 month - Visit 1
|
ERH, infantile amnesia, book reading, frustration, cooperation
|
513 (49%)
|
48 month - Visit 2
|
Memory
|
462 (44%)
|
48 months - Visit 3
|
Language
|
28 (12%)
|
Ambulatory Mood Assessment Survey
Timepoint
|
Completed
|
0 – 1 month
|
13 (21%)
|
1 – 3 month
|
26 (21%)
|
3 –5 month
|
28 (21%)
|
Other Measures
Physiological & Neuroimaging
|
MRI
|
Mom: 162 completed
|
Baby: 79 completed
|
Dyad: 77 completed
|
Electrophysiology: 4 months (in person)
|
39
|
Biospecimens: Cord blood, placental tissue, maternal blood
|
78 completed
|
Infant Stool Sample: Birth
|
23 completed
|
Behavioral & Sensory
|
Smell tests: 2 months
|
457 completed
|
Sleep Actiography: 18–24 months
|
61 completed
|
Socialization Goals Inventory (SGI) Interview: 8–12 months
|
85 completed
|
Strange Situation Procedure: 12–18 months
|
In Office: 23
|
Remote: 24
|
Qualitative & Psychosocial
|
Qualitative Interviews (NOSI)
|
64 completed
|
