Michael R Rosen, MD

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Overview

Dr. Michael R. Rosen is the Gustavus A. Pfeiffer Professor of Pharmacology and Professor of Pediatrics at the College of Physicians and Surgeons of Columbia University in New York. He is also Adjunct Professor of Physiology and Biophysics at Stony Brook University and a member of Stony Brook’s Institute for Molecular Cardiology. 

Dr. Rosen received the Bachelor of Arts degree from Wesleyan University in 1960 and the Doctor of Medicine degree from the State University of New York Downstate Medical Center in 1964. He subsequently trained in internal medicine and cardiology at Montefiore Hospital in New York, served in the United States Air Force and then as a postdoctoral fellow in the Department of Pharmacology at Columbia University. He joined the faculty of that department in 1972 and has remained there throughout his career. 

Dr. Rosen has authored or co-authored more than 500 peer-reviewed manuscripts. His research interests initially focused on the electrophysiology and pharmacologic prevention and treatment of cardiac arrhythmias. In the 1970s he and his colleagues identified afterdepolarizations as an important cause of cardiac arrhythmias and studied the mechanisms and clinical implications of triggered activity, work that has had major clinical impact. Other areas of investigation explored by Dr. Rosen and associates are developmental changes in ion channels and the autonomic nervous system; the mechanisms whereby altered activation of the heart temporarily or permanently induces epigenetic changes in molecular-biophysical pathways that alter the expression of repolarization; and gene and stem cell therapies. The most advanced aspect of the latter research is on biological pacing, where creation of an alternative to electronic pacing is being sought. This work was supported by a number of granting agencies over the years, with the major source being a Program Project Grant funded by NHLBI for 25 years. In 2013, Dr. Rosen terminated all his administrative responsibilities and has focused since that time on teaching and on advising regarding research and development. 

In addition to his scientific accomplishments, Dr. Rosen has contributed to science-related activities in the academic and lay communities. These activities include chairing the Basic Science Council and the Scientific Program Committee of the American Heart Association, and as an activist in issues of broader perspective, such as public and political education on the importance of science to society and the protection of scientific funding for this mission. He has served on three NIH and two American Heart Association Study Sections, on the recombinant DNA advisory committee at NIH, on the review committee for the California Institute of Regenerative Medicine and on a stem cell research oversight committee for the Swiss National Science Foundation. He was editor of the Journal of Cardiovascular Pharmacology, a consulting editor for Cardiovascular Research and member of the editorial boards of Circulation, Circulation Research, and Heart Rhythm. 

Among the awards/degrees Dr. Rosen has received are: Doctor Honoris Causa of the Russian Academy of Sciences, the American Heart Association’s Award of Merit, the AHA Chairman’s Award, and the AHA Distinguished Achievement Award; Leiden University’s Einthoven Award; the Heart Rhythm Society’s Distinguished Scientist Award, the Gordon K. Moe Lectureship of the Cardiac Electrophysiology Society, Samuel Seifter, Ph.D. Award: Master Teacher in the Basic Sciences, SUNY Downstate Medical Center, and the Mirowski Award of Excellence in Clinical Cardiology and Electrophysiology.

Academic Appointments

  • Gustavus A. Pfeiffer Professor of Pharmacology and Professor of Pediatrics

Languages

  • French

Credentials & Experience

Education & Training

  • MD, FACP, FAHA, 1964 Medicine, S.U.N.Y. Downstate Medical Center

Honors & Awards

Honorary Degrees

Professor Honoris Causa, Russian Academy of Sciences, 2008

Honors (Selected)

Alpha Omega Alpha, 1963

Fellow, American College of Physicians, 1973-

Fellow, American College of Clinical Pharmacology, 1975-

Honorary Member: Argentine Association of Cardiac Pharmacology; 1985 -

Honorary Regent for Life: American College of Clinical Pharmacology, 1985 -

William N. Creasy Visiting Professor of Clinical Pharmacology (Burroughs-Wellcome Fund): Wayne

State University; April, 1988

Distinguished Alumnus Award: Polytechnic Preparatory C.D. School, 1991

Award of Merit: American Heart Association, 1992

Samuel Seifter, Ph.D. Award: Master Teacher in the Basic Sciences, SUNY Downstate Medical Center, 1994

Fellow, European Society of Cardiology, 1999-2014; Emeritus Fellow, 2014-

Chairman’s Award: American Heart Association, 2000

Founding Fellow, International Society for Heart Research, 2001-2015; Emeritus Fellow, 2015-

Fellow, American Heart Association, 2001-2014; Emeritus Fellow, 2014-

Einthoven Award; The Einthoven Foundation; Leiden, The Netherlands, 2002

Distinguished Scientist Award: Heart Rhythm Society, San Francisco, CA, 2004

Distinguished Achievement Award: AHA Council on Basic Cardiovascular Sciences, 2005

Fellow of the Heart Rhythm Society, 2006-2014: Emeritus Fellow 2014-

Honorary Member, Russian Society for Clinical Electrophysiology, Arrhythmology and Cardiac Pacing,

2009-

Mirowski Award of Excellence in Clinical Cardiology & Electrophysiology, Heart Rhythm Society, 2014

Research

Developmental biology of the heart; cardiac-autonomic interactions; Mechanisms for cardiac arrhythmias and their prevention and control

Selected Publications

Ben-Ari M, Schick R, Barad L, Novak A, Ben-Ari E, Lorber A, Itskovitz-Eldor J, Rosen MR, Weissman A, Binah O, From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects, Heart Rhythm, 2014;11:1808-1818.

 

Harleton E, Besana A, Chandra P, Danilo P, Rosen T, Rosen MR, Argenziano M, Robinson RB, Feinmark SJ. TASK-1 current Is inhibited by phosphorylation during human and canine chronic atrial fibrillation. Am J Physiol Heart Circ Physiol. 2015;308:H126-34

 

Meijborg VM, Chauveau S, Janse MJ, Anyukhovsky EP, Danilo PR Jr, Rosen MR, Opthof T, Coronel R. Interventricular dispersion in repolarization causes bifid T waves in dogs with dofetilide-induced long QT syndrome. Heart Rhythm. 2015;12:1343-1351.

 

Li N, Csepe TA, Hansen BJ, Dobrzynski H, Higgins RSD, Kilic A, Mohler PJ, Janssen PML, Rosen MR, Biesiadecki BJ, Fedorov VV. Molecular mapping of sinoatrial node HCN channel expression in the human heart. Circulation Arrhythmias and Electrophysiology, 2015. 8:1219-1227

 

Rosen MR, Bergfeldt L. Cardiac memory: The slippery slope twixt normalcy and pathology. Trends Cardiovasc Med. 2015: 25:687-696. 

 

Qiu XS, Chauveau S, Anyukhovsky EP, Rahim T, Jiang Y-P, Harleton E, Feinmark SJ, Lin RZ, Coronel R, Janse MJ, Opthof T, Rosen TS, Cohen IS, MD, Rosen MR. Increased late sodium current contributes to the electrophysiological effects of chronic, but not acute, dofetilide administration. Circulation Arrhythmias and Electrophysiology. 2016: 9:e003655. DOI: 10.1161/CIRCEP.115.003655.

 

Ben-Ari M, Naor S, Zeevi-Levin N, Schick R, Jehuda RB, Reiter I, Raveh A, Grijnevitch I, Barak O, Rosen MR, Weissman A, Binah O. Developmental changes in electrophysiological characteristics of human  Induced pluripotent stem cell-derived cardiomyocytes. Heart Rhythm. 2016 Sep 14. pii: S1547-5271(16)30745-7. doi: 10.1016/j.hrthm.2016.08.045.

 

Chauveau S, Anyukhovsky EP, Ben-Ari M, Naor S, Jiang Y-P, Danilo P Jr., Rahim T, Burke S, Qiu X, Potapova IA, Doronin SV, Brink PR, Binah O, Cohen IS, Rosen MR: Induced pluripotent stem cell-derived cardiomyocytes provide in vivo biological pacemaker function. Circulation, Arrhythmias and Electrophysiology. 2017: 10:e004508. DOI: 10.1161/CIRCEP.116.004508.

 

Lin RZ, Lu Z, MD, Anyukhovsky EA, Jiang Y-P, Wang HZ, Gao J, Rosen MR, Ballou LM, Cohen IS: Regulation of heart rate and the pacemaker current IF independently of the autonomic nervous system by phosphoinositide 3-kinase signaling. J Gen Physiol. 2019; 151: 1066–1069.