IXA Awards for Dr. Kazuhiko Yamada and the Yamada Lab

The Xeno Prize is awarded to the first author of the best paper published in the journal Xenotransplantation each calendar year. This prize is jointly sponsored by the International Xenotransplantation Association (IXA) and the publisher of Xenotransplantation (Wiley).

The 2018 Xeno-Prize was awarded to Dr. Kazuhiko Yamada during the IXA meeting in Munich, for his article entitled "GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.”

Dr. Yamada’s lab has several projects that are aimed to induce tolerance across both allogeneic and xenogeneic barriers using large animals. His research projects have been supported by NIH grants as well as other research foundation support.

Additionally, two of Dr. Yamada’s researchers have been chosen as recipients of the IXA 2020 Young Investigator Awards, which aims to shine a light on the crucial roles of mentors in introducing the recipients to the study of xenotransplantation, encouraging them, and providing support and friendship that allows them to grow and flourish in their careers and lives.

Yuichi Ariyoshi (Columbia University Medical Center, USA) became interested in xenotransplantation by reading an article published by Dr. Kazuhiko Yamada before joining his lab at Columbia several years later, while Kazuhiro Takeuchi (Columbia University Medical Center, USA) was encouraged by his mentor to join the Yamada lab around the same time.

Kazuhiro wants to continue research in pathology regarding kidney transplantation and he believes that kidney xenotransplantation, including the tolerance strategy that he is working on in Columbia will be successful. Yuichi feels that by incorporating gene modification and overcoming immunologic issues, islet and/or kidney xenotransplantation will undergo clinical trials in the US within 5-10 years and he hopes to perform clinical kidney xenotransplantation in Japan.

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